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However, the involvement of transcription factors in neuropathic pain is poorly understood. In this study, we report that transcription factor (TF) ETS proto-oncogene 1 (ETS1) is required for the initiation and development of neuropathic pain. Sciatic nerve chronic constrictive injury (CCI, a clinical neuropathic pain model) increases ETS1 expression in the injured male mouse DRG. Blocking this upregulation alleviated CCI-induced mechanical allodynia and thermal hyperalgesia, with no apparent effect on locomotor function. Mimicking this upregulation results in the genesis of nociception hypersensitivity; mechanistically, nerve injury-induced ETS1 upregulation promotes the expression of histone deacetylase 1 (HDAC1, a key initiator of pain) via enhancing its binding activity to the HDAC1 promotor, leading to the elevation of spinal central sensitization, as evidenced by increased expression of p-ERK1\/2 and GFAP in the dorsal spinal horn. It appears that the ETS1\/HDAC1 axis in DRG may have a critical role in the development and maintenance of neuropathic pain, and ETS1 is a potential therapeutic target in neuropathic pain.<\/jats:p>","DOI":"10.1177\/17448069231152125","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:04:16Z","timestamp":1672963456000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons"],"prefix":"10.1177","volume":"19","author":[{"given":"Hong-Li","family":"Zheng","sequence":"first","affiliation":[{"name":"Graduate School, Wannan Medical College, Wuhu, China"},{"name":"Department of Pain, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai, 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