{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:34Z","timestamp":1790740654287,"version":"4.1.0"},"reference-count":64,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016305","name":"The First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Natural Science Foundation","award":["81200909"],"award-info":[{"award-number":["81200909"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>Resolvin D1 (RvD1) suppresses inflammatory, postoperative, and neuropathic pain. The present study assessed the roles and mechanisms of RvD1 in mechanical allodynia after burn injury. A rat model of burn injury was established for analyses, and RvD1 was injected intraperitoneally. Pain behavior and the expression levels of spinal dorsal horn Iba-1 (microglia marker), GFAP (astrocyte marker), p-p38 mitogen-activated protein kinase (MAPK), brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase B (TrkB) were detected by behavioral and immunocytochemical assays. The results showed that RvD1 attenuated mechanical allodynia after burn injury, prevented microglial and astroglial activation, and downregulated p-p38 MAPK in microglia and BDNF\/TrkB following burn injury. Similarly, inhibition of p38 MAPK and BDNF\/TrkB signaling attenuated mechanical allodynia after burn injury. In addition, inhibition of p38 MAPK prevented spinal microglial activation and downregulated BDNF\/TrkB following burn injury. Furthermore, inhibition of BDNF\/TrkB signaling prevented spinal microglial activation and downregulated p-p38 MAPK within spinal microglia. Taken together, this study demonstrated that RvD1 might attenuate mechanical allodynia after burn injury by inhibiting spinal cord glial activation, microglial p38 MAPK, and BDNF\/TrkB signaling in the spinal dorsal horn.<\/jats:p>","DOI":"10.1177\/17448069231159970","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T00:07:00Z","timestamp":1676074020000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor\/tropomyosin-related kinase B signaling"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6861-148X","authenticated-orcid":false,"given":"Xiaona","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Pain and Perioperative Medicine, The 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