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The sepaconitine amine group formed hydrophobic interactions with key residues. The Lappaconitine benzene ring contributed to hydrophobic interactions and hydrogen bond acceptor interactions. The hydrophobic interactions of the ranaconitine amine group play a critical role with specific residues on Nav1.8 and Nav1.9.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The natural fusicoccane diterpenoid derivatives Sepaconitine, Lappaconitine, and Ranaconitine are potential lead compounds for the development of novel analgesics as selective antihyperalgesic drugs, which will provide a new dental pharmacological intervention for managing painful dental pulp conditions. Further experimental validation and clinical studies that confirm the efficacy and safety of these compounds will strengthen their applicability in dental practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17448069251327824","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:28:42Z","timestamp":1741746522000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>In silico<\/i>\n                    exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp"],"prefix":"10.1177","volume":"21","author":[{"given":"Ravinder S","family":"Saini","sequence":"first","affiliation":[{"name":"Department of Allied Dental Health Sciences, COAMS, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayan Ibrahim H","family":"Binduhayyim","sequence":"additional","affiliation":[{"name":"Department of Allied Dental Health Sciences, COAMS, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Saheer","family":"Kuruniyan","sequence":"additional","affiliation":[{"name":"Department of Allied Dental Health Sciences, COAMS, King Khalid University, Abha, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-3205","authenticated-orcid":false,"given":"Artak","family":"Heboyan","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"34","article-title":"Bacterial infections of pulp and periodontal origin","volume":"9","author":"Gonz\u00e1lez-Moles MA","year":"2004","unstructured":"Gonz\u00e1lez-Moles MA, Gonz\u00e1lez NM. 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