{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:05:54Z","timestamp":1779883554960,"version":"3.53.1"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Pioneer and Leading Goose R&D Program of Zhejiang Province 2023","award":["2023C04049"],"award-info":[{"award-number":["2023C04049"]}]},{"name":"Ningbo International Collaboration Program 2023","award":["2023H025"],"award-info":[{"award-number":["2023H025"]}]},{"name":"Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation"},{"name":"Zoe Ltd and the National Institute for Health Research"},{"name":"Clinical Research Network"},{"name":"Biomedical Research Centre"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic variants associated with widespread pain by utilizing the extensive UK Biobank dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a primary genome-wide association study (GWAS) using a novel definition of widespread pain, defined as pain experienced all over the body during the past month. Sex-stratified GWAS analysis approach was also performed to analyze the impact of sex on widespread pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The primary GWAS identified one novel significant genetic locus (rs34691025,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 1.76 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      ) on chromosome 5q13.2 within the\n                      <jats:italic toggle=\"yes\">ARHGEF28<\/jats:italic>\n                      gene and several loci that approached genome-wide significance. The sex-stratified GWAS outputs revealed biological difference widespread pain between males and females, with a novel locus identified in the female-specific analysis within the\n                      <jats:italic toggle=\"yes\">LRMDA<\/jats:italic>\n                      gene on chromosome 10. Genetic Correlation analysis demonstrated significant genetic correlations between widespread pain and other phenotypes, including joint disorders and spondylosis. The PheWAS revealed associations between the significant genetic variants with hearing disorders and cardiovascular diseases. A two-sample Mendelian randomization analysis found no significant causal association between hearing loss and widespread pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study advances the understanding of the genetic factors contributing to widespread pain, highlighting notable differences between males and females and identifying a novel genetic locus associated with this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17448069251346603","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T02:39:44Z","timestamp":1749782384000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (\n                    <i>N<\/i>\n                    = 172,230)"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-9122","authenticated-orcid":false,"given":"Qi","family":"Pan","sequence":"first","affiliation":[{"name":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengda","family":"Cai","sequence":"additional","affiliation":[{"name":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Tao","sequence":"additional","affiliation":[{"name":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luning","family":"Yang","sequence":"additional","affiliation":[{"name":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Compte","sequence":"additional","affiliation":[{"name":"Department Twin Research and Genetic Epidemiology, School of Life Course Science, King\u2019s College London, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam Kazemi","family":"Naeini","sequence":"additional","affiliation":[{"name":"Department Twin Research and Genetic Epidemiology, School of Life Course Science, King\u2019s College London, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mainul","family":"Haque","sequence":"additional","affiliation":[{"name":"School of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Dottorini","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances MK","family":"Williams","sequence":"additional","affiliation":[{"name":"Department Twin Research and Genetic Epidemiology, School of Life Course Science, King\u2019s College London, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-8494","authenticated-orcid":false,"given":"Weihua","family":"Meng","sequence":"additional","affiliation":[{"name":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, Zhejiang, China"},{"name":"Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK"},{"name":"Center for Public Health, Faculty of Medicine, Health and Life Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen\u2019s University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000417"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2019-0054"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010364"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000314"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001819"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12302"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.21798"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201742"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219624"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2012.89"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.11.011"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq419"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00913-z"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes10070554"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0481-0"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8641-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.064964"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.02.021"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/10738584211030493"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex308"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2021.105222"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2012.758288"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02224-9"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302200200"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030658"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304565200"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00632-8"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4691-05.2006"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008164"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009428"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010977"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12982"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0637-y"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0640-3"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25266"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181808c4e"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00823.x"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2014.02.009"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069251346603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069251346603","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069251346603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:20:35Z","timestamp":1777710035000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069251346603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":44,"alternative-id":["10.1177\/17448069251346603"],"URL":"https:\/\/doi.org\/10.1177\/17448069251346603","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.16.24307395","asserted-by":"object"}]},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]},"article-number":"17448069251346603"}}