{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:59:27Z","timestamp":1792799967104,"version":"4.5.0"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bethune Medical Research Fund","award":["2022-YJ-085-J-Z-ZZ-013"],"award-info":[{"award-number":["2022-YJ-085-J-Z-ZZ-013"]}]},{"name":"the project of State key laboratory of radiation medicine and protection","award":["GZK12023017"],"award-info":[{"award-number":["GZK12023017"]}],"id":[{"id":"https:\/\/ror.org\/02av90z31","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University","award":["YXY2304035"],"award-info":[{"award-number":["YXY2304035"]}]},{"name":"international team of gastrointestinal tumor","award":["SZYJTD201804"],"award-info":[{"award-number":["SZYJTD201804"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Utidelone (UTD1), a recently approved epothilones analog in China for metastatic breast cancer, is endorsed in combination with capecitabine for metastatic breast cancer patients who have encountered first-line therapy failures. Despite its clinically verified therapeutic efficacy, it is concurrently associated with peripheral neuropathic pain, particularly affecting extremities. However, the etiology of UTD1-induced peripheral neuropathic pain remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The present investigation built a mouse pain model induced by UTD1, resulting in marked mechanical and cold allodynia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Examination of the dorsal root ganglia unveiled a notable upregulation of TRPA1, accompanied by noteworthy alterations in oxidative stress-related markers, including ATF4, SOD2, CAT, and Cyt-C. The TRPA1 antagonist HC-030031, resulted in the alleviation of mechanical and cold allodynia in the UTD1-induced pain model, as well as two antioxidants, including Mito-tempo and edaravone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation:<\/jats:title>\n                    <jats:p>The present study will provide new strategies for pain relieving induced by UTD1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17448069251377633","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T06:48:15Z","timestamp":1756450095000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Utidelone induces mechanical and cold allodynia in mice via TRPA1 activation"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0798-8691","authenticated-orcid":false,"given":"Wenwen","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"},{"name":"Department of Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-3377","authenticated-orcid":false,"given":"Cunjin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-5870","authenticated-orcid":false,"given":"Yusong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China"},{"name":"State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.03.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.12.006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0297-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30088-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.29"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1571-6"},{"key":"e_1_3_2_9_2","first-page":"91","volume-title":"TRP channels","author":"Numata T","year":"2011","unstructured":"Numata T, Kiyonaka S, Kato K, Takahashi N, Mori Y. 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