{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:12:07Z","timestamp":1789063927857,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Youth Talent Cultivation Fund Project of Dalian Medical University"},{"DOI":"10.13039\/501100010086","name":"Foundation of Liaoning Province Education Administration","doi-asserted-by":"publisher","award":["LJKMZ20221276"],"award-info":[{"award-number":["LJKMZ20221276"]}],"id":[{"id":"10.13039\/501100010086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023-MS-262"],"award-info":[{"award-number":["2023-MS-262"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Program of the Medical-Engineering Joint Innovation Fund of the First Affiliated Hospital of Dalian Medical University and Dalian Institute of Chemical Physics, Chinese Academy of Sciences","award":["DMU-1&DICP UN202304"],"award-info":[{"award-number":["DMU-1&DICP UN202304"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>It has well been documented that sex-related difference in the prevalence of migraine is widely accepted with more commonly seen in female patients. Although trigeminal ganglion (TG) neurons are the key players in the etiology of migraine, the underlying pathophysiology remains under debate so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Myelinated Ah-type TG neurons were identified by the waveform characters of action potential (AP) conjugated with pharmacological validation using whole-cell patch techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results showed that AP duration and current derivative for repolarization were markedly increased by 3 \u00b5M Yoda1 along with the increased firing frequency of repetitive discharge that could be abolished by 3 \u00b5M GsMTx4. Although Yoda1 concentration-dependently increased the peaks of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      currents, the blocker for Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channel \u03c9-Conotoxin did not alter the AP waveform characters and discharge profiles, whereas Yoda1-mediated changes in AP waveform trajectory and repetitive discharge could be completely reversed by 1.0 \u00b5M Iberiotoxin, a selective KCa1.1 blocker, suggesting that Piezo1-induced Ca\n                      <jats:sup>2+<\/jats:sup>\n                      influx can activate KCa1.1 via presumably channel coupling. Additionally, Ah-type TG neurons functionally expressed Nav1.9\/Nav1.8 in all tested neurons and their peaks were significantly increased by 3 \u00b5M Yoda1 and completely blocked by 3 \u00b5M GsMTx4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These datasets have demonstrated Piezo1-mediated neuroexcitation of female-specific subpopulation of myelinated Ah-type TG neurons due at least to the coupling between N-type Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channel and KCa1.1 and functional upregulation of Nav1.9, which uncovers an additional insights for higher incidence of migraine in woman.\n                    <\/jats:p>\n                  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