{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:32:05Z","timestamp":1777944725775,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"abstract":"<jats:p>Spinal cord injury (SCI) triggers a cascade of secondary insults\u2014including vascular disruption, excitotoxicity, oxidative stress, inflammation, and apoptosis\u2014that worsen neurological outcomes. Among the molecular mediators, transient receptor potential (TRP) channels have emerged as pivotal regulators of SCI pathology. Distinct subtypes contribute to diverse processes: TRPV1 and TRPA1 drive pain hypersensitivity and inflammation, TRPM2 and TRPM7 amplify oxidative injury and barrier breakdown, TRPC6 shapes astrocyte reactivity, while TRPML1 may confer neuroprotection via autophagy. Although these insights highlight TRPs as attractive therapeutic targets, clinical translation is hampered by widespread channel distribution, poor selectivity of available modulators, and systemic toxicity. Advancing SCI treatment will require innovative strategies to selectively modulate TRP signaling, exploit targeted delivery systems, and integrate TRP modulation into multimodal therapeutic approaches.<\/jats:p>","DOI":"10.1177\/17448069261422992","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:03:09Z","timestamp":1770004989000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["EXPRESS: A Road to Recovery: Transient Receptor Potential (TRP) Channels as Therapeutic Avenues for Spinal Cord Injury"],"prefix":"10.1177","author":[{"given":"Mohammad Amin","family":"Manavi","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirhossein","family":"Charmchi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Yegani","sequence":"additional","affiliation":[{"name":"Faculty of Paramedical Sciences, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Nejati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh","family":"Mohammad Jafari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8001-5565","authenticated-orcid":false,"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2]]},"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261422992","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261422992","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:21:05Z","timestamp":1777710065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069261422992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":0,"alternative-id":["10.1177\/17448069261422992"],"URL":"https:\/\/doi.org\/10.1177\/17448069261422992","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"17448069261422992"}}