{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:40:52Z","timestamp":1782333652375,"version":"3.54.5"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR079178"],"award-info":[{"award-number":["R01AR079178"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["R01MD010441"],"award-info":[{"award-number":["R01MD010441"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    This secondary data analysis aimed to determine the nature of the relationship between obstructive sleep apnea (OSA) risk, biological age acceleration, and nonspecific chronic low back pain (CLBP). In total, 199 adults aged 18\u201382 years who filled both STOPBANG and pain questionnaires subsetted for secondary analysis. Based on the STOPBANG questionnaire, 104 had a low OSA risk and 95 had an intermediate or high OSA risk. Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE), Horvath\u2019s, Hannum\u2019s, PhenoAge, and GrimAge clocks were used to determine biological age and pace of biological aging. Individuals with low OSA risk reported increased DunedinPACE compared to those with intermediate\/high OSA risk (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). There was a significant correlation between the risk for OSA and biological age acceleration measured by PhenoAge as well as pace of biological aging (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). Mediation analysis detected indirect effects of OSA risk on chronic pain outcomes through the pace of biological aging. Targeted interventions addressing OSA risk offers a promising therapeutic strategy. This could be particularly valuable for aging populations where both accelerated biological aging and chronic pain conditions are prevalent, offering a more holistic approach to improving nonspecific chronic pain outcomes through quality of sleep and restfulness.\n                  <\/jats:p>","DOI":"10.1177\/17448069261427979","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:54:51Z","timestamp":1771329291000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond restless sleep: A cross-sectional study of obstructive sleep apnea risk, aging biomarkers, and chronic low back pain"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1795-2927","authenticated-orcid":false,"given":"Khalid W","family":"Freij","sequence":"first","affiliation":[{"name":"Department of Acute, Chronic &amp; Continuing Care, Nurse Anesthesia Program, School of Nursing, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9169-5064","authenticated-orcid":false,"given":"Fiona BAT","family":"Agbor","sequence":"additional","affiliation":[{"name":"Department of Acute, Chronic &amp; 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Behavioral Neurobiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid W","family":"Freij","sequence":"additional","affiliation":[{"name":"Vaughan Regional Medical Center Sleep Center, Vaughan Regional Medical Center, Selma, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shameka L","family":"Cody","sequence":"additional","affiliation":[{"name":"Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Neurobiology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E","family":"Sorge","sequence":"additional","affiliation":[{"name":"Department of Psychology, College of Arts and Sciences, The University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burel R","family":"Goodin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, School of Medicine, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-0870","authenticated-orcid":false,"given":"Edwin N","family":"Aroke","sequence":"additional","affiliation":[{"name":"Department of Acute, Chronic &amp; 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