{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:04:38Z","timestamp":1780452278077,"version":"3.54.1"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIH\/NCI","award":["R01CA208623"],"award-info":[{"award-number":["R01CA208623"]}]},{"name":"NIH\/NCI","award":["R21CA269099"],"award-info":[{"award-number":["R21CA269099"]}]},{"name":"NIH\/NINDS","award":["1R01NS139461"],"award-info":[{"award-number":["1R01NS139461"]}]},{"name":"NIH\/NINDS","award":["R21NS135646"],"award-info":[{"award-number":["R21NS135646"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and dose-limiting side effect of oxaliplatin treatment, yet its molecular mechanisms remain incompletely understood. Calcitonin gene-related peptide alpha (CGRP\u03b1, encoded by\n                    <jats:italic toggle=\"yes\">Calca<\/jats:italic>\n                    ) is a neuropeptide implicated in several chronic pain conditions and has been proposed to mediate CIPN-related hypersensitivity. Here, we investigated the role of CGRP\u03b1 in a mouse model of chronic oxaliplatin-induced neuropathy. Mice treated with oxaliplatin over 8 weeks developed cold allodynia and reduced sensory nerve conduction velocity, recapitulating hallmark clinical symptoms of chronic CIPN. However, contrary to expectations, we observed no increase in\n                    <jats:italic toggle=\"yes\">Calca<\/jats:italic>\n                    mRNA expression or protein levels in the dorsal root ganglia (DRG) of male mice and a significant decrease in female mice. The proportion of CGRP-expressing neurons remained unchanged. RNA-seq revealed a two-fold upregulation of\n                    <jats:italic toggle=\"yes\">Ramp1<\/jats:italic>\n                    , a subunit of the CGRP receptor complex. These results suggest that CGRP\u03b1 signaling may be enhanced not by increased peptide expression, but rather by increased calcium-dependent release from existing neurons and increased CGRP receptor sensitization. This is consistent with known effects of oxaliplatin-induced oxidative stress, which can activate TRPA1 channels and promote calcium-dependent vesicular release of neuropeptides. Although additional validation of this model is needed, our data support a revised rationale of CGRP involvement in CIPN based on sensitization and neuropeptide release, rather than upregulation, and point to TRPA1\u2013CGRP interactions as a potential therapeutic target in oxaliplatin-induced neuropathic pain.\n                  <\/jats:p>","DOI":"10.1177\/17448069261432028","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:30:33Z","timestamp":1772195433000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["CGRP expression and signaling sensitization in a mouse model of chronic oxaliplatin-induced peripheral neuropathy"],"prefix":"10.1177","volume":"22","author":[{"given":"Junwei","family":"Du","sequence":"first","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Institute of Materials Science &amp; Engineering, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leland C","family":"Sudlow","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret H","family":"Johnson","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanishk","family":"Satish","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Villagomez","sequence":"additional","affiliation":[{"name":"Paul L. Foster School of Medicine, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-2487","authenticated-orcid":false,"given":"Mikhail Y","family":"Berezin","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Institute of Materials Science &amp; Engineering, Washington University, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.643824"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.14302\/issn.2372-6601.jhor-25-5944"},{"key":"e_1_3_3_4_2","first-page":"1043","article-title":"Prospective evaluation of the incidence of delayed nausea and vomiting in patients with colorectal cancer receiving oxaliplatin-based chemotherapy","volume":"20","author":"Hesketh PJ","year":"2012","unstructured":"Hesketh PJ, Sanz-Altamira P, Bushey J, Hesketh AM. Prospective evaluation of the incidence of delayed nausea and vomiting in patients with colorectal cancer receiving oxaliplatin-based chemotherapy. 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