{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:49:26Z","timestamp":1777945766825,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Commission of Xiamen, Xiamen Natural Science Foundation Project","award":["3502Z20214ZD123"],"award-info":[{"award-number":["3502Z20214ZD123"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this paper is to expound the effect of asiatic acid (AA) on psoriasis via modulating the PI3K\/Akt\/NF-\u03baB pathway and NLRP3 inflammasome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>An imiquimod (IMQ)-induced psoriasis model in BALB\/c mice was established. Mice were divided into the control, IMQ, and AA treatment groups with different doses. Psoriasis area and severity were scored using the Psoriasis Area Severity Index (PASI). Histological changes, inflammatory factor levels in skin lesions, and expressions of NLRP3 inflammasome-related proteins and pathway proteins were measured. For cellular experiments, HaCaT cells were classified into control, model, AA low and high concentration groups, and AA-H + IGF group. Cells were stimulated with IL-17A, IL-22, TNF-\u03b1, IL-1\u03b1, and OSM (M5) to induce psoriasis-like conditions, followed by treatment with AA or IGF. Cell viability, oxidative stress levels, inflammatory factors, NLRP3 expression, and PI3K\/Akt\/NF-\u03baB pathway protein levels were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In vivo, IMQ-induced mice showed psoriasis-like symptoms, including increased PASI scores, IL-6, TNF-\u03b1, IL-17A, and NLRP3-related protein levels. AA treatment alleviated these symptoms, reducing NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), and Caspase-1 expression, and restraining the PI3K\/Akt\/NF-\u03baB pathway phosphorylation. In cellular experiments, M5 induction impeded cell viability and advanced oxidative stress, IL-1\u03b2, IL-6, and NLRP3 expression, activating the PI3K\/Akt\/NF-\u03baB pathway. AA markedly reversed these change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AA alleviates psoriasis symptoms by blocking the PI3K\/Akt\/NF-\u03baB pathway and NLRP3 inflammasome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17448069261435785","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:20:42Z","timestamp":1773386442000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of asiatic acid in relieving psoriasis by modulating the PI3K\/Akt\/NF-\u03baB pathway and NLRP3 inflammasome"],"prefix":"10.1177","volume":"22","author":[{"given":"Juan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatologic and Venereal Disease, Xiamen Changgung Hospital, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukadas","family":"Dilishti","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice, The People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatologic and Venereal Disease, Xiamen Changgung Hospital, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tungchun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatologic and Venereal Disease, Xiamen Changgung Hospital, Xiamen, Fujian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4909-072X","authenticated-orcid":false,"given":"Mengzhuang","family":"Liu","sequence":"additional","affiliation":[{"name":"General Medical Practice Section, The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People\u2019s Hospital), Heyuan, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"97","article-title":"Current developments in the immunology of psoriasis","volume":"93","author":"Gran F","year":"2020","unstructured":"Gran F, Kerstan A, Serfling E, Goebeler M, Muhammad K. Current developments in the immunology of psoriasis. 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