{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:54:50Z","timestamp":1781787290357,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Bone metastasis\u2013associated pain is a major cause of morbidity in advanced renal cell carcinoma (RCC), and effective therapies that concurrently mitigate pain and intraosseous tumor burden remain limited. Here, we evaluated dezocine as a potential dual-action agent and explored the involvement of the NAMPT\/NAD\n                    <jats:sup>+<\/jats:sup>\n                    axis. In 786-O cells, dezocine dose-dependently suppressed proliferation (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 73.6 \u03bcM), clonogenicity and increased apoptosis, accompanied by reduced NAMPT expression and a decreased NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/NADH ratio. Pharmacological rescue with the NAMPT activator SBI-797812 partially reversed these effects. In vivo, using an intra-tibial RCC cell inoculation model that recapitulates osteolysis and cancer-induced bone pain (CIBP), dezocine alleviated mechanical allodynia and thermal hyperalgesia, and reduced osteolytic bone destruction and intraosseous tumor progression; co-administration of SBI-797812 partially attenuated these effects (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 6). Tumor tissues from dezocine-treated mice showed decreased Ki67 and NAMPT, increased cleaved caspase-3, and enhanced AMPK phosphorylation, consistent with metabolic stress\u2013associated apoptosis. Collectively, these findings suggest that dezocine may provide dual analgesic and antitumor benefits in intraosseous RCC lesions, at least in part by suppressing the NAMPT\/NAD\n                    <jats:sup>+<\/jats:sup>\n                    axis, supporting further translational evaluation for bone metastasis\u2013associated pain management.\n                  <\/jats:p>","DOI":"10.1177\/17448069261460286","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:26:12Z","timestamp":1780662372000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dezocine alleviates cancer-induced bone pain and suppresses intraosseous tumor growth in renal cell carcinoma via the NAMPT\/NAD+ axis"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7008-5103","authenticated-orcid":false,"given":"Lijun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Affiliated People\u2019s Hospital of Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cixian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated People\u2019s Hospital of Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated People\u2019s Hospital of Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Affiliated People\u2019s Hospital of Ningbo University, Ningbo, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e3282f9782b"},{"issue":"7","key":"e_1_3_3_3_2","first-page":"537","article-title":"Expert consensus on renal cell carcinoma with bone metastasis (2020 Edition)","volume":"42","author":"Diagnosis and Therapy for Bone Metastasis of Malignant Tumor and Skeletal-Related Event Expert Group","year":"2020","unstructured":"Diagnosis and Therapy for Bone Metastasis of Malignant Tumor and Skeletal-Related Event Expert Group. Expert consensus on renal cell carcinoma with bone metastasis (2020 Edition). Zhonghua Zhong Liu Za Zhi 2020; 42(7): 537\u2013542.","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2024.102792"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0034-9"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000048"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy152"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph18030386"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.600296"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2022-0541"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfac026"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.117"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107509"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0197"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2022.106189"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11078-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2024.100167"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2018.01.002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S356863"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.189033"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02161-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02095-8"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261460286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069261460286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261460286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:16:29Z","timestamp":1781784989000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069261460286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":21,"alternative-id":["10.1177\/17448069261460286"],"URL":"https:\/\/doi.org\/10.1177\/17448069261460286","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"article-number":"17448069261460286"}}