{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:16:09Z","timestamp":1788023769095,"version":"build-2784847793"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Medical and Health Science and Technology Research Program of Zhejiang Province","award":["2024KY433"],"award-info":[{"award-number":["2024KY433"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25C040003"],"award-info":[{"award-number":["LMS25C040003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Medical Association Clinical Medical Research Fund Key Project","award":["2023ZYC-Z39"],"award-info":[{"award-number":["2023ZYC-Z39"]}]},{"name":"Zhejiang Clinovation Pride-Herpes Zoster Neuralgia","award":["CXTD202502014"],"award-info":[{"award-number":["CXTD202502014"]}]},{"name":"Zhejiang Provincial Key Clinical Discipline-Department of Anesthesiology","award":["2023-ZJZK-001"],"award-info":[{"award-number":["2023-ZJZK-001"]}]},{"name":"Jiaxing Medical Key Supporting Discipline Anesthesiology"},{"name":"Jiaxing Provinces and Cities Jointly Cultivate Discipline-General Surgery","award":["2023-PYXK-001"],"award-info":[{"award-number":["2023-PYXK-001"]}]},{"name":"Zhejiang Provincial Multi disciplinary TCM Innovation Team for the Diagnosis and Treatment of Headache and Vertigo in the Elderly"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Central post-stroke pain (CPSP) remains difficult to treat due to limited understanding of its underlying mechanisms. Emerging evidence implicates microglia-driven neuroinflammation in CPSP development. Mitogen-activated protein kinase phosphatase-1 (MKP-1) negatively regulates MAPK signaling and modulates inflammation in neurological disorders, yet its role in CPSP is unclear. Using a mouse model of thalamic hemorrhage, we examined MKP-1 expression and function in CPSP. Behavioral testing assessed pain hypersensitivity and affective disturbances. Immunofluorescence and western blot evaluated MKP-1 expression, microglial activation, and inflammatory signaling in the thalamus. Pharmacological MKP-1 inhibition was employed to assess functional contributions. Thalamic hemorrhage induced persistent mechanical hypersensitivity and anxiety-like behaviors, accompanied by pronounced microglial activation in the peri-lesional thalamus. MKP-1 expression increased significantly after stroke and localized primarily to microglia. MKP-1 inhibition exacerbated pain behaviors and enhanced microglial activation, with corresponding increases in pro-inflammatory mediators and p38 MAPK phosphorylation. These findings suggest that MKP-1 may function as an endogenous negative regulator of microglia-mediated neuroinflammation following thalamic hemorrhage. Pharmacological modulation of MKP-1 signaling warrants further investigation as a potential approach for CPSP.<\/jats:p>","DOI":"10.1177\/17448069261484390","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:15:00Z","timestamp":1787775300000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological inhibition of MKP-1 exacerbates central post-stroke pain and neuroinflammation in mice"],"prefix":"10.1177","volume":"22","author":[{"given":"Yong","family":"Fei","sequence":"first","affiliation":[{"name":"Zhejiang University"},{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Meng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanrui","family":"Fan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bu","sequence":"additional","affiliation":[{"name":"Shenzhen Traditional Chinese Medicine Hospital"},{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1959-8185","authenticated-orcid":false,"given":"Longsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiaxing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-yao","family":"Li","sequence":"additional","affiliation":[{"name":"Zhejiang University"},{"name":"Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70176-0"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31819d644c"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02765-2"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/17448069211063351"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-013-3761-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00228914"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.5.679"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv389"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibra.12140"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153375"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2018.2"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00715"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3621"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.022"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3119"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.11.007"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.025"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.10.006"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.11.019"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051753"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1310"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108746"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8786-6"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510965103"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2025.115936"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11264-x"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S531280"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/03946320241309220"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10187-3"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12823"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-025-01638-z"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20965786"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23672"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.05.011"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.11.011"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102262"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.05.030"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4053"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175449"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.3.472"}],"container-title":["Molecular Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261484390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17448069261484390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17448069261484390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:20:27Z","timestamp":1788020427000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17448069261484390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"alternative-id":["10.1177\/17448069261484390"],"URL":"https:\/\/doi.org\/10.1177\/17448069261484390","relation":{},"ISSN":["1744-8069","1744-8069"],"issn-type":[{"value":"1744-8069","type":"print"},{"value":"1744-8069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"article-number":"17448069261484390"}}