{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:10:39Z","timestamp":1788667839496,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-25413539"],"award-info":[{"award-number":["RS-2025-25413539"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Mol Pain"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Pain is a major clinical outcome in chronic inflammatory disease, yet molecular correlates of within-person pain change remain unclear and must be distinguished from inflammatory change. We used longitudinal whole-blood multi-omics data from the RA-MAP\/TACERA early rheumatoid arthritis cohort to prioritize microRNA (miRNA) candidates whose 6-month changes co-varied with change in visual analogue scale pain (\u0394VAS). Among 151 participants and 1,881 miRNA features, we applied a stability-oriented delta-omics workflow combining subsampling elastic-net selection frequency, bootstrap directional filtering, and post-selection rank-residual partial correlation adjusted for \u0394CRP and \u0394ESR. This identified 29 directionally stable miRNA candidates; after \u0394CRP\/\u0394ESR adjustment, 16 retained sign-consistent support at post-selection BH-FDR &lt; 0.05 within these 29 candidates. Matched miRNA\u2013mRNA delta analysis found no individual miRNA\u2013mRNA pair surviving pair-level BH-FDR correction. At the primary nominal pair-selection threshold of p &lt; 0.05, 123 inverse pairs involving 117 target genes yielded exploratory Gene Ontology Biological Process enrichment involving synaptic and neuronal organization; however, no GO term remained BH-significant when the pair-selection threshold was tightened to p &lt; 0.01. The exploratory plasma chronic neck pain comparison yielded 22 of 39 sign-consistent assay matches (56.4%; exact 95% CI, 39.6%\u201372.2%), which was not statistically distinguishable from the 50% chance expectation, and no match survived BH-FDR correction. These findings outline a stability-oriented, inflammation-adjusted approach for prioritizing blood miRNA candidates linked to pain change. The 16-miRNA subset should be interpreted as a hypothesis-generating candidate pool rather than a validated biomarker panel and provides a focused basis for future longitudinal validation and functional studies.<\/jats:p>","DOI":"10.1177\/17448069261487017","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:30:16Z","timestamp":1788532216000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-blood miRNA candidate prioritization for longitudinal pain change suggests synaptic and neuronal organization pathway involvement in early rheumatoid arthritis"],"prefix":"10.1177","volume":"22","author":[{"given":"Heejeong","family":"Shin","sequence":"first","affiliation":[{"name":"Dongguk University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Dongguk University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-727X","authenticated-orcid":false,"given":"Seung-Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Dongguk University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2023.09.008"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019055108"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.006"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1301545"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1744806920962925"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.06.001"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S567154"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/17448069251401661"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01264-y"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X211043977"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477973"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2010.00740.x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2008.00674.x"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2005.00503.x"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_3_6_18_2","first-page":"275","article-title":"False discovery rates: a new deal","volume":"18","author":"Stephens M","year":"2017","unstructured":"Stephens M. 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