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While peripheral nerve injury is a key driver, emerging evidence suggests that maladaptive plasticity within central pain circuits, including the anterior cingulate cortex (ACC), contributes to the maintenance of neuropathic pain. Here, we tested the hypothesis that the ACC is a critical substrate for cisplatin-induced mechanical allodynia and a target for cannabigerol (CBG)-mediated antinociception. Adult male C57BL\/6 mice received cisplatin (5 mg\/kg, i.p., once weekly for four weeks) to induce CIPN. Mechanical allodynia was assessed using electronic von Frey testing. Systemic administration of CBG (20 mg\/kg, i.p.) significantly reversed mechanical allodynia in CIPN mice without affecting baseline thresholds in non-neuropathic animals, indicating a state-dependent effect. Chemogenetic inhibition of ACC neurons using hM4Di DREADDs similarly attenuated mechanical allodynia, identifying the ACC as a functionally relevant component of the CIPN pain state. To determine whether CBG acts within this circuit, bilateral intra-ACC microinjections of CBG (20 nM and 20 \u00b5M) were performed, both of which produced transient antinociceptive effects. These findings demonstrate that the ACC contributes to the maintenance of mechanical allodynia in CIPN and establish this region as a site of action for CBG. Together, our results support a model in which the ACC represents a convergent cortical mechanism underlying pathological pain and highlight the potential for centrally targeted, non-euphoriant cannabinoid-based therapies.<\/jats:p>","DOI":"10.1177\/17448069261491110","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:27:25Z","timestamp":1789518445000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The anterior cingulate cortex mediates cisplatin-induced mechanical allodynia and represents a target for cannabigerol antinociception"],"prefix":"10.1177","volume":"22","author":[{"given":"Matheus Vinicius","family":"Ferreira","sequence":"first","affiliation":[{"name":"Penn State College of Medicine"},{"name":"Federal University of Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Morris","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn","family":"Wade","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joice Maria","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-7029","authenticated-orcid":false,"given":"Nicholas","family":"Graziane","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06042-x"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2025.102921"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2026.106646"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2212394120"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.68"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.03.038"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14001"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919831909"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00224"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/17448069241300990"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1290-1"},{"key":"e_1_3_5_14_2","first-page":"1747","article-title":"Efferents of anterior cingulate areas 24a and 24b and midcingulate areas 24a' and 24b' in the mouse","volume":"223","author":"Fillinger C","year":"2018","unstructured":"Fillinger C, Yalcin I, Barrot M, et al. 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