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The UKCTOCS was large enough for sufficient accrual and follow-up, using two intervention arms: MMS (a multimodal strategy using the biomarker Ca125 combined with ultrasound as a secondary test) and USS (ultrasound alone) compared against a no-screen control group. MMS and USS performed similarly, showing a statistically significant reduction in mortality that increased with follow-up surveillance (8% reduction in years 0\u20137 vs 28% in years 7\u201314). The data led to the estimate that 641 screens are needed to prevent one ovarian cancer death.\n                  <\/jats:p>","DOI":"10.1177\/1745505716666096","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:40:24Z","timestamp":1483630824000},"page":"475-479","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ovarian cancer screening effectiveness: A realization from the UK Collaborative Trial of Ovarian Cancer Screening"],"prefix":"10.1177","volume":"12","author":[{"given":"Edward J","family":"Pavlik","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Kentucky Chandler Medical Center and the Markey Cancer Center, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01224-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.766"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70026-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318238d030"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.01035.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5646"},{"key":"e_1_3_2_8_2","unstructured":"US Preventive Services Task Force. 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