{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:34:15Z","timestamp":1792593255035,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Caesarean section, a common obstetric surgical procedure, is a major predisposing factor for puerperal infections, requiring the need for antibiotic prophylaxis. Evidence suggests that single-dose antibiotic prophylaxis has comparable efficacy to multiple-dose antibiotic prophylaxis, but with a lower cost and risk of antibiotic resistance. However, single-dose antibiotic prophylaxis after caesarean section is not generally used in many centres in sub-Saharan Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to compare the effectiveness of single- versus multiple-dose antibiotic prophylaxis to prevent post-caesarean section infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>This open-label, randomized controlled trial involved 162 consenting patients admitted for caesarean section (elective or emergency) at the Federal Medical Centre Keffi. They were distributed randomly into treatment arm A or B. Subjects in both arms received intravenous ceftriaxone (1\u2009g) and metronidazole (500\u2009mg) 30\u201360\u2009min before incision; subjects in arm B received additional parenteral doses for 48\u2009h and then cefuroxime 500\u2009mg tablets every 12\u2009h and metronidazole 400\u2009mg tablets every 8\u2009h for 5\u2009days. The patients were monitored for 2\u2009weeks for evidence of wound infection, febrile morbidity and clinical endometritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>There was no statistical difference in the incidence of wound infection (6.6% versus 7.4%; p\u2009=\u2009.882) and febrile morbidity (11.8% versus 11.1%, p\u2009=\u2009.807). However, clinical endometritis (0.0% versus 6.1%, p\u2009=\u2009.028) was statistically significant with none reported in the single-dose arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Single-dose ceftriaxone and metronidazole is as effective as multiple doses for antibiotic prophylaxis to prevent post-caesarean section infections. Adoption of this approach in low-risk patients would reduce the cost of prophylactic antibiotics, workload for staff and antibiotic resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057221101071","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T06:58:12Z","timestamp":1654585092000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Single-dose versus multiple-dose antibiotics prophylaxis for preventing caesarean section postpartum infections: A randomized controlled trial"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0180-0432","authenticated-orcid":false,"given":"Gerald Tochukwu","family":"Igwemadu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-2152","authenticated-orcid":false,"given":"George Uchenna","family":"Eleje","sequence":"additional","affiliation":[{"name":"Effective Care Research Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enang Enang","family":"Eno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uche Augustine","family":"Akunaeziri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folashade Adeola","family":"Afolabi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and 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