{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:34:50Z","timestamp":1777944890105,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Primary Health Care Corporation","award":["PHCC\/DCR\/2020\/09\/104"],"award-info":[{"award-number":["PHCC\/DCR\/2020\/09\/104"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent worldwide among pregnant women. Although vitamin D supplementation is effective in improving vitamin D status, the safety and optimal dosing of vitamin D supplementation during pregnancy remain less well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to investigate the prevalence of vitamin D deficiency among pregnant women and evaluate the effectiveness of vitamin D supplementation in improving vitamin D status during pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This prospective cohort study assessed the impact of a 16-week daily vitamin D supplementation 1000\u2009IU regimen on vitamin D status among pregnant women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 365 pregnant women were recruited, and their baseline total circulating 25-hydroxy vitamin D concentrations were measured. Of these, 249 participants completed the study, which involved oral daily supplementation with 1000\u2009IU of vitamin D and a repeat of total circulating 25-hydroxy vitamin D concentrations after 16\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study found that 57.7% of the participants had vitamin D deficiency, consistent with the rates reported in other studies. However, vitamin D supplementation at a dose of 1000\u2009IU had a small effect size and was not clinically significant. However, 67% of participants with vitamin D deficiency remained deficient; among participants initially with vitamin D insufficiency, 30% became deficient. Moreover, 26.5% of individuals with sufficient vitamin D status at 12\u2009weeks showed insufficient levels by 28\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vitamin D deficiency is widespread among pregnant women, and vitamin D supplementation at a daily dose of 1000\u2009IU may not adequately address this problem. Although the study has limitations, its results align with previous research and may apply to other populations with a high prevalence of vitamin D deficiency during pregnancy. Further research is necessary to determine the most effective approach for addressing prenatal vitamin D deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057231222404","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T02:24:37Z","timestamp":1706495077000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prospective cohort study of vitamin D deficiency in pregnancy: Prevalence and limited effectiveness of 1000 IU vitamin D supplementation"],"prefix":"10.1177","volume":"20","author":[{"given":"Rasha Mohammed","family":"Abdelmageed","sequence":"first","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suha Majeed Mohammed","family":"Hussein","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamil Mohamed","family":"Anamangadan","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rola Walid Mahmoud","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Rauf","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AlAnoud Saleh","family":"AlFehaidi","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-1424","authenticated-orcid":false,"given":"Ehab","family":"Hamed","sequence":"additional","affiliation":[{"name":"Qatar University Health Centre, Primary Health Care Corporation, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"bibr1-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.05.011"},{"key":"bibr2-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.3.362"},{"key":"bibr3-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0736"},{"key":"bibr4-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"bibr5-17455057231222404","unstructured":"Vitamin D: health professional fact sheet, https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-HealthProfessional\/ (accessed 24 June 2023)."},{"key":"bibr6-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"bibr7-17455057231222404","doi-asserted-by":"publisher","DOI":"10.4161\/derm.25111"},{"key":"bibr8-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2017.14"},{"key":"bibr9-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-029334"},{"key":"bibr10-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665121001944"},{"key":"bibr11-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30457-7"},{"key":"bibr12-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12210"},{"key":"bibr13-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1990850"},{"key":"bibr14-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1186\/s41043-021-00253-y"},{"key":"bibr15-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1159\/000487370"},{"key":"bibr16-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.08.015"},{"key":"bibr17-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy071"},{"key":"bibr18-17455057231222404","doi-asserted-by":"publisher","DOI":"10.3390\/nu10050640"},{"key":"bibr19-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.019"},{"key":"bibr20-17455057231222404","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016404"},{"key":"bibr21-17455057231222404","volume-title":"WHO recommendation regarding vitamin D supplementation during pregnancy","author":"WHO","year":"2011"},{"key":"bibr22-17455057231222404","unstructured":"The American College of Obstetricians & Gynecologists (ACOG). 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