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Despite these advancements, there is a growing interest in less invasive alternatives. This review delves into the potential of high-intensity focused ultrasound (HIFU). HIFU employs focused ultrasound waves for precise ablation of adenomyotic lesions. The review conducts a thorough analysis of HIFU principles, safety, efficacy, and its possible synergies with other therapies. HIFU seems to be effective for adenomyosis treatment, demonstrating a favorable adverse effect profile and suitability for fertility preservation. Combining HIFU with hormonal treatment appears to enhance long-term symptom control, presenting a promising and comprehensive approach for managing adenomyosis. The goal of this article is to develop a comprehensive understanding of HIFU\u2019s role in contemporary adenomyosis management and to explore areas requiring further research.<\/jats:p>","DOI":"10.1177\/17455057241295593","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T07:17:21Z","timestamp":1730704641000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["High-intensity focused ultrasound in adenomyosis treatment: Insights on safety, efficacy, and reproductive prospects"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6427-1355","authenticated-orcid":false,"given":"Shadha Nasser","family":"Bahutair","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila Yahya","family":"Alhubaishi","sequence":"additional","affiliation":[{"name":"Obs&gyne and uro-gynecologist Dubai Health Latifa hospital, Dubai, United Arab Emirates Consultant Obs&gyne and uro-gynecologist Dubai Health-Latifa hospital Chairperson of scientific committee of Obs&gyne Emirati board In NIHS-UAE University"},{"name":"Dubai Academic Health Corporation, Dubai, United Arab Emirates"},{"name":"Emirati Board-NIHS, Al Ain, United Arab Emirates"},{"name":"United Arab Emirates University, Al Ain, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"issue":"2","key":"bibr1-17455057241295593","first-page":"129","volume":"38","author":"Zhai J","year":"2020","journal-title":"Semin Reprod Med"},{"key":"bibr2-17455057241295593","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2014.01.001"},{"key":"bibr3-17455057241295593","doi-asserted-by":"crossref","unstructured":"Gordts S, Grimbizis G, Campo R. 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