{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:34:09Z","timestamp":1777944849989,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Pfizer Inc. and Sumitomo Pharma America, Inc."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endometriosis symptoms have multifaceted manifestations, and there are few approved nonsurgical treatment options. Gonadotropin-releasing hormone (GnRH) agonists\/antagonists for endometriosis vary on efficacy, safety profile, and out-of-pocket (OOP) cost, among other features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study quantified the importance that women with endometriosis in the United States (US) placed on pain and non-pain features that differ among these medications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>English-speaking, 18 to 50\u2009years (premenopausal) US women with healthcare coverage for the past 3\u2009years, who self-reported a laparoscopy-confirmed endometriosis diagnosis, were recruited via healthcare research panels to complete a cross-sectional survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A discrete choice experiment (DCE) with a surgery opt-out option assessed preferences for eight GnRH agonist\/antagonist attributes (reducing different types of pain, treatment administration, impact on daily activities, etc.). Best-worst scaling (BWS) assessed preferences for 11 non-pain medication attributes (dosage flexibility, short treatment onset, reversible side effects, etc.). Relative importance (RI) was estimated for each attribute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, 300 women were included (mean age 33.0\u2009years; 76.7% White). Across DCE choice tasks, GnRH agonist\/antagonist was chosen over surgery 46.7% of the time. Non-menstrual pelvic pain relief (RI\u2009=\u200923.1%), reducing monthly OOP cost (RI\u2009=\u200922.1%), and relief of dyspareunia (RI\u2009=\u200921.4%) and dysmenorrhea (RI\u2009=\u200912.9%) were most important for GnRH treatment choice. Among non-pain attributes in the BWS, short onset of treatment effect (RI\u2009=\u200913.1%), long-term safety (RI\u2009=\u200912.9%), and reducing fatigue (RI\u2009=\u200911.2%) were most important to women when choosing a pharmacologic endometriosis treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Relieving the three types of endometriosis pain and reducing cost are the most important considerations for women when selecting GnRH agonist\/antagonist treatment. Women with endometriosis strongly prefer a medication that can be safely taken for longer periods of time, takes effect within a few menstrual cycles, and can reduce endometriosis-related fatigue. Findings can inform discussions between patients and healthcare providers to better align endometriosis treatment decision-making with patients\u2019 individual needs and preferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057251331700","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T13:50:22Z","timestamp":1757253022000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Attribute preferences associated with gonadotropin-releasing hormone agonists\/antagonists among women with endometriosis in the United States"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-5315","authenticated-orcid":false,"given":"Martine C.","family":"Maculaitis","sequence":"first","affiliation":[{"name":"RWE Data &amp; Analytics, Oracle Life Sciences, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Kim","sequence":"additional","affiliation":[{"name":"Patient &amp; Health Impact, Pfizer Inc, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-0554","authenticated-orcid":false,"given":"Elke","family":"Hunsche","sequence":"additional","affiliation":[{"name":"Global Market Access &amp; HEOR, Sumitomo Pharma Switzerland GmbH, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Beusterien","sequence":"additional","affiliation":[{"name":"RWE Data &amp; Analytics, Oracle Life Sciences, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cislo","sequence":"additional","affiliation":[{"name":"Statistical Research and Data Science Center, Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole T.","family":"Ansani","sequence":"additional","affiliation":[{"name":"Medical Affairs, Pfizer Inc., New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-7268","authenticated-orcid":false,"given":"Brett","family":"Hauber","sequence":"additional","affiliation":[{"name":"Worldwide Medical and Safety, Pfizer Inc, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"issue":"9","key":"e_1_3_5_2_2","article-title":"The clinical anatomy of endometriosis: a review","volume":"10","author":"Alimi Y","year":"2018","unstructured":"Alimi Y, Iwanaga J, Loukas M, et al. 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