{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:04:23Z","timestamp":1789376663018,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Neuroendocrine metastases to the ovaries are extremely rare, with approximately 100 cases reported in the English literature. The most frequent primary source is a small bowel neuroendocrine tumor (NET), particularly of ileal origin, and patients often present with widespread metastases and carcinoid syndrome. We report the case of a 46-year-old North African woman who presented with hot flashes, motility diarrhea, and a cutaneous rash of the neckline persisting for 3\u2009months, initially misattributed to perimenopause. Imaging revealed bilateral ovarian masses classified as ORADS 4. Surgical exploration found bilateral adnexal tumors and multiple peritoneal nodules; a total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and nodule resection were performed. Histology revealed bilateral ovarian involvement by a well-differentiated NET, also affecting peritoneal nodules. The primary origin was unclear, prompting comprehensive staging, including an octreoscan, computed tomography scan, and enteric magnetic resonance imaging, which revealed retractile mesenteritis and a 4-cm mass involving the cecum and terminal ileum, along with mesenteric lymphadenopathy. A right hemicolectomy with resection of 1\u2009m of small bowel and mesenteric nodes confirmed a well-differentiated NET of the cecum and ileum with negative surgical margins. The patient was started on long-acting repeatable octreotide. This case underlines the importance of considering a neuroendocrine origin in perimenopausal women presenting with symptoms suggestive of carcinoid syndrome, as these may be mistaken for menopausal changes.<\/jats:p>","DOI":"10.1177\/17455057251374505","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:04:25Z","timestamp":1789196665000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ovarian metastasis from neuroendocrine tumor presenting as hot flashes: A case report and literature review"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8426-7804","authenticated-orcid":false,"given":"Eya","family":"Rahmouni","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Bouhani","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfa","family":"Jaidane","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanen","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloua","family":"Krichen","sequence":"additional","affiliation":[{"name":"Department of Histology, Habib Bourguiba Hospital, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Ben","family":"Dhiab","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2024.08.059"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.02.040"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad035"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17414"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17222"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22266"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17392"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.02.034"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-201554"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70410-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ebb2a5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21493"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000287277"},{"key":"e_1_3_3_15_2","first-page":"7149821","article-title":"Neuroendocrine cancer of rectum metastasizing to ovary","volume":"2016","author":"Amin SV","year":"2016","unstructured":"Amin SV, Devi BN, Vankalakunti M, et al. Neuroendocrine cancer of rectum metastasizing to ovary. Case Rep Oncol Med 2016; 2016: 7149821.","journal-title":"Case Rep Oncol Med"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.09.002"},{"issue":"3","key":"e_1_3_3_17_2","article-title":"Carcinoid syndrome: a review","volume":"12","author":"Gade AK","year":"2020","unstructured":"Gade AK, Olariu E, Douthit NT. Carcinoid syndrome: a review. 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