{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:34:11Z","timestamp":1777944851302,"version":"3.51.4"},"reference-count":62,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Brain-derived neurotrophic factor (BDNF) is associated with the development of different psychiatric conditions, including eating disorders (EDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To investigate the salivary BDNF\u2019s ability to act as a potential biomarker for detecting the risk of developing EDs among young females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and methods:<\/jats:title>\n                    <jats:p>A cross-sectional study was carried out in Amman, Jordan, with a total of 216 nutrition students completing the Eating Attitudes Test-26 (EAT-26) to assess the risk of developing EDs, the Cohens\u2019 Perceived Stress Scale-10 (PSS-10) to measure stress levels, and the International Physical Activity Questionnaire-Short Form (IPAQ-SF) to assess physical activity levels. Dietary intake was analyzed using a semiquantitative food frequency questionnaire. A nested sample of 34 females from both extreme EDs was selected and tested for salivary BDNF levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The nested sample of 34 female nutrition students 22.00 (2.75) years old with body mass index (BMI) of 23.60 (3.35) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were divided into two groups; 18 students were at lower risk, while 16 were at higher risk of developing EDs. The salivary BDNF levels did not differ significantly between the low-risk and high-risk groups (391.03 (128.17), 339.15 (102.52), and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.347, respectively). BMI, PSS-10 score, and total metabolic equivalent (MET) were significantly different between the two groups. No associations were found between salivary BDNF levels and BMI, PSS-10 score, MET, or different food groups. The odds ratio for the risk of BDNF-related EDs was 1.07 (95% CI, 1.03\u20131.10) in the higher-risk group versus the lower-risk group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>BDNF is not a robust biomarker of risk for EDs. The changes in salivary BDNF levels could reflect individual ED eating patterns rather than indicating a direct causative role in the disorder\u2019s development. According to our results, psychiatric consultation for ED detection remains the gold standard for diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057251376885","type":"journal-article","created":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:08:41Z","timestamp":1759064921000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary BDNF to predict at-risk status of eating disorders in young nutritionist Jordanian females: Results from a preliminary multistage study"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-2341","authenticated-orcid":false,"given":"Aseel","family":"AlSaleh","sequence":"first","affiliation":[{"name":"Aseel AlSaleh Department of Family and Community Medicine, College of Medicine and Health Sciences, Arabian Gulf University, Manama, 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