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Management typically involves lifestyle changes, including increased physical activity and reduced sedentary behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To compare the health profiles and behaviours of women with and without PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This study analysed data from the UK Biobank, which is a prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Women with PCOS in the UK Biobank were identified, while age- and body mass index (BMI)-matched controls were randomly selected. Data on factors associated with PCOS severity and self-reported lifestyle behaviours were analysed. Group differences were tested for significance, and participants were categorised by health behaviours to assess morbidity risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study included 319 women with PCOS (mean age: 43.9\u2009years) and 638 in each control group. Significant differences (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) were observed in anthropometric (e.g. body weight, BMI, waist and hip circumference, and body fat), cardio-metabolic (e.g. blood pressure, triglycerides, and glycated haemoglobin), and androgenic (e.g. sex hormone-binding globulin) indices. Differences were most pronounced between PCOS and age-matched controls but remained when BMI was also considered. Women with PCOS engaged in less vigorous physical activity and had higher screen time and sedentary behaviours. Those with the lowest physical activity and highest sedentary time had the worst health profiles and highest morbidity risk, regardless of group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Women with PCOS exhibit poorer health despite only slight lifestyle differences. Across all participants, lower physical activity and higher sedentary behaviour were linked to increased health risks. Further research is needed to clarify causal relationships between lifestyle factors and PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057251385800","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T09:13:41Z","timestamp":1763716421000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic, androgenic, and physical activity profiles in women aged over 40\u2009years with polycystic ovary syndrome: A comparative analysis using UK Biobank data"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-274X","authenticated-orcid":false,"given":"Chris","family":"Kite","sequence":"first","affiliation":[{"name":"School of Health and Wellbeing, Faculty of Education, Health and Wellbeing, University of Wolverhampton, UK"},{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, UK"},{"name":"Division of Public Health, Sport and Wellbeing, Faculty of Health, Medicine and Society, University of Chester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-3439","authenticated-orcid":false,"given":"Ioannis","family":"Kyrou","sequence":"additional","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, UK"},{"name":"Centre for Sport Exercise &amp; Life Sciences, Coventry University, UK"},{"name":"Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, UK"},{"name":"Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK"},{"name":"Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal S.","family":"Randeva","sequence":"additional","affiliation":[{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, UK"},{"name":"Centre for Sport Exercise &amp; Life Sciences, Coventry University, UK"},{"name":"Division of Translational and Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-2876","authenticated-orcid":false,"given":"Ian M.","family":"Lahart","sequence":"additional","affiliation":[{"name":"School of Sport, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Walsall, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E. 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