{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:34:54Z","timestamp":1777944894464,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["1901090266"],"award-info":[{"award-number":["1901090266"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016714","name":"University of Sharjah","doi-asserted-by":"publisher","award":["22010902116"],"award-info":[{"award-number":["22010902116"]}],"id":[{"id":"10.13039\/100016714","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endometrial hyperplasia, a precursor to endometrial cancer, is increasing due to rising obesity and lifestyle risks. Scarce data exist on the molecular characterization of endometrial hyperplasia for prognostic and preventive applications,<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study investigates the expression of core pluripotency stem cell markers in endometrial hyperplasia, given their emerging role in cancer stem cell regulation in various cancers, including endometrial cancer,<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>This is a case\u2013control study utilizing archival endometrial tissue blocks. In this study, we assessed the immunohistochemical expression of NANOG, OCT4, and SOX2 in hyperplastic endometrium compared to benign non-hyperplastic endometrium obtained from women with abnormal uterine bleeding,<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The investigation included 165 patients (83 cases with endometrial hyperplasia and 82 controls). The prevalence of endometrial hyperplasia in our cohort was 20.8% (of 500 patients). NANOG showed moderate to high expression in 60.2% of endometrial hyperplasia cases, significantly higher than in controls (19.5%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.0005. OCT4 showed moderate\/high expression in 12% of endometrial hyperplasia cases compared to 3.7% of controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045). In comparison, SOX2 was expressed in 18% of endometrial hyperplasia with no significant difference from controls (19.7%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.823. Logistic regression showed that age and NANOG expression were significant predictors of endometrial hyperplasia risk, with women exhibiting moderate\/high NANOG expression having an 11-fold increased risk of endometrial hyperplasia (95% confidence interval of odds ratio: 3.484\u201335.864,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Using receiver operating characteristic curves, women\u2019s age predicted SOX2 expression in endometrial hyperplasia cases (area under the curve (AUC)\u2009=\u20090.867, cutoff\u2009=\u200949\u2009years, Youden\u2019s index\u2009=\u20090.722, sensitivity\u2009=\u2009100%, specificity\u2009=\u200972.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and NANOG in controls (AUC\u2009=\u20090.734, cutoff\u2009=\u200942\u2009years, Youden\u2019s index\u2009=\u20090.37, sensitivity\u2009=\u200968.8%, specificity\u2009=\u200968.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NANOG shows promise for a potential predictive role in patients with endometrial hyperplasia, with moderate\/high expression indicating a higher risk. SOX2\u2019s role was unclear but age-related. Further studies are needed to validate these findings and explore hormonal links.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057251408631","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:05:34Z","timestamp":1769515534000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of pluripotency stem cell markers in endometrial hyperplasia"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-6776","authenticated-orcid":false,"given":"Noha A.","family":"Mousa","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates"},{"name":"Department of Obstetrics and Gynecology, University Hospital Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeinab","family":"Al-Rawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Family &amp; Community Medicine and Behavioral Sciences, College of Medicine, University of Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdalla","family":"Suliman","sequence":"additional","affiliation":[{"name":"Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-0761","authenticated-orcid":false,"given":"Ghada","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Medicine, University of Sharjah, United Arab Emirates"},{"name":"Department of Obstetrics and Gynecology, University Hospital Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifat","family":"Hamoudi","sequence":"additional","affiliation":[{"name":"Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, United Arab Emirates"},{"name":"Division of Surgery and Interventional Science, Faculty of Medical Science, University College London, UK"},{"name":"Biomedically Informed Artificial Intelligence Laboratory (BIMAI-Lab), University of Sharjah, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suha","family":"Al-Naimi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, University of Sharjah, United Arab Emirates"},{"name":"School of Health and Science, University of Suffolk, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"SEER*Explorer: an interactive website for SEER cancer statistics. 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