{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:35:04Z","timestamp":1777944904403,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000770","name":"university of manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000770","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"cancer research uk","doi-asserted-by":"publisher","award":["EDDAMC-2021\/100003"],"award-info":[{"award-number":["EDDAMC-2021\/100003"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"stanford university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"university of cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018071","name":"knight cancer institute, oregon health and science university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"university college london","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013684","name":"christie charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013684","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manchester Cancer Research Centre"},{"DOI":"10.13039\/100014653","name":"manchester biomedical research centre","doi-asserted-by":"publisher","award":["NIHR203308"],"award-info":[{"award-number":["NIHR203308"]}],"id":[{"id":"10.13039\/100014653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Breast cancer rates are increasing globally amongst premenopausal women, who often face aggressive subtypes with poorer outcomes than postmenopausal women. In the United Kingdom, current guidelines for risk assessment amongst women under age 50\u2009years focus on family history or genetic predisposition, a strategy that fails to identify most women that go on to develop breast cancer. The Breast CANcer Risk Assessment in Younger women (BCAN-RAY) study is evaluating the feasibility and acceptability of a novel risk assessment strategy for women aged 30\u201339\u2009years, without a strong family history, incorporating a risk factor questionnaire, polygenic risk score and breast density assessment to identify those at increased risk and support early screening and preventive health measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate the acceptability of the BCAN-RAY approach to assessing risk by exploring women\u2019s views of the invitation, risk assessment and feedback processes used, to identify any changes required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A cross-sectional qualitative design was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-two women from the BCAN-RAY study identified as being either at population average (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911) or at increased risk (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911) of developing breast cancer completed semi-structured interviews shortly after receiving risk feedback. Data were analysed thematically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Participants generally found the BCAN-RAY approach acceptable, with no evidence of significant anxiety during or after participation. Positive experiences were largely attributed to personalised staff interactions and the availability of tailored opportunities to manage risk. However, some participants reported confusion regarding risk information provided, for example, struggling with technical language. Practical barriers, including logistical challenges and limitations of existing referral pathways, were also identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Breast cancer risk assessment amongst younger women was generally acceptable with results allowing participants to be proactive about their health. Issues related to risk communication, training of staff who will conduct risk assessment and streamlining the delivery of risk assessment need to be considered for routine implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057261435107","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:17:20Z","timestamp":1777029440000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acceptability of breast cancer risk assessment amongst general population women aged 30\u201339\u2009years: A qualitative study"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0678-5483","authenticated-orcid":false,"given":"Rosie","family":"Horton","sequence":"first","affiliation":[{"name":"Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-1177","authenticated-orcid":false,"given":"Sarah","family":"Hindmarch","sequence":"additional","affiliation":[{"name":"Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sacha J.","family":"Howell","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-2531","authenticated-orcid":false,"given":"Juliet A.","family":"Usher-Smith","sequence":"additional","affiliation":[{"name":"Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Gorman","sequence":"additional","affiliation":[{"name":"NIHR Greater Manchester Patient Safety Research Collaboration, Division of Population Health, Health Services Research &amp; Primary Care, Faculty of Biology, Medicine and Health, University of Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Gareth","family":"Evans","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, Division of Evolution, Infection and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK"},{"name":"St Mary\u2019s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-7804","authenticated-orcid":false,"given":"David P.","family":"French","sequence":"additional","affiliation":[{"name":"Manchester Centre for Health Psychology, Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"5748","article-title":"Global incidence and mortality of breast cancer: a trend analysis","volume":"13","author":"Huang J","year":"2021","unstructured":"Huang J, Chan PS, Lok V, et al. Global incidence and mortality of breast cancer: a trend analysis. Aging (Albany N Y) 2021; 13: 5748\u20135803.","journal-title":"Aging (Albany N Y)"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.776"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.3.1387"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.05.001"},{"key":"e_1_3_3_6_2","article-title":"Epidemiology and prognosis of breast cancer in young women","volume":"5","author":"Assi HA","year":"2013","unstructured":"Assi HA, Khoury KE, Dbouk H, et al. Epidemiology and prognosis of breast cancer in young women. J Thorac Dis 2013; 5: S2\u2013S8.","journal-title":"J Thorac Dis"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.102"},{"key":"e_1_3_3_8_2","unstructured":"Office for National Statistics. Deaths registered in England and Wales: 2022 https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/bulletins\/deathsregistrationsummarytables\/2022 (2023 accessed 8 February 2024)."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111791"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600008"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.24.1879"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1668"},{"key":"e_1_3_3_13_2","unstructured":"National Institute for Health and Care Excellence (NICE). Familial breast cancer: classification care and managing breast cancer and related risks in people with a family history of breast cancer [updated 2019 Nov] (Clinical Guideline [CG164]) https:\/\/www.nice.org.uk\/guidance\/cg164\/chapter\/Recommendations (2013 accessed 8 February 2024)."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30891-4"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9816"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0838"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05210-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab036"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109019"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0388-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-017-0035-5"},{"key":"e_1_3_3_22_2","unstructured":"UNICANCER. My Personalized Breast Screening (MyPeBS). ClinicalTrials.gov identifier: NCT03672331 https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03672331 (2018 accessed 23 January 2024)."},{"key":"e_1_3_3_23_2","unstructured":"Manchester University NHS Foundation Trust. Breast CANcer Risk Assessment in Younger women: BCAN-RAY (BCAN-RAY). ClinicalTrials.gov identifier: NCT04336904 https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05305963 (2022 accessed 8 February 2024)."},{"key":"e_1_3_3_24_2","article-title":"A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance","volume":"374","author":"Skivington K","year":"2021","unstructured":"Skivington K, Matthews L, Simpson SA, et al. A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance. BMJ 2021; 374: n2061.","journal-title":"BMJ"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-078555"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02268-0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08347-w"},{"key":"e_1_3_3_28_2","article-title":"Optimising the delivery of breast cancer risk assessment for women aged 30\u201339\u2009years: a qualitative study of women\u2019s views","volume":"19","author":"Hindmarch S","year":"2023","unstructured":"Hindmarch S, Gorman L, Hawkes RE, et al. Optimising the delivery of breast cancer risk assessment for women aged 30\u201339\u2009years: a qualitative study of women\u2019s views. Womens Health (Lond) 2023; 19: 17455057231160348.","journal-title":"Womens Health (Lond)"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/tomography9060165"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/ad470b"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0406-9"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-024-00729-4"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049732315617444"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2031-8"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/2159676X.2019.1628806"},{"key":"e_1_3_3_38_2","volume-title":"Thematic analysis: a practical guide","author":"Braun V","year":"2021","unstructured":"Braun V, Clarke V. Thematic analysis: a practical guide. SAGE Publications Inc., 2021."},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1037\/qup0000196"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1057\/sth.2013.17"},{"key":"e_1_3_3_41_2","unstructured":"Ministry of Housing Communities and Local Government. English indices of deprivation 2019 https:\/\/imd-by-postcode.opendatacommunities.org\/imd\/2019 (2019 accessed 10 May 2025)."},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/16094069211054920"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1177\/1049732306290130"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02250-w"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02156-7"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjhp.12678"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01944-x"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.56"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3726-y"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06745-0"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2018.11.002"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbi\/wbab001"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.2196\/formative.9935"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-062079"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261435107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17455057261435107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261435107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:30:44Z","timestamp":1777710644000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17455057261435107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["10.1177\/17455057261435107"],"URL":"https:\/\/doi.org\/10.1177\/17455057261435107","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"17455057261435107"}}