{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:03:26Z","timestamp":1779782606486,"version":"3.53.1"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Duodenal metastasis from endometrial cancer is exceedingly rare, with only seven cases reported in the literature. While endometrial cancer typically spreads to lymph nodes, lungs, and the peritoneum, gastrointestinal involvement, particularly in the duodenum, is an uncommon and diagnostically challenging occurrence. We report the case of a 49-year-old woman initially treated for a stage IIIC2, grade 2 endometrioid adenocarcinoma via total hysterectomy, lymphadenectomy, and adjuvant radiochemotherapy. After 1\u2009year of complete remission, she presented with epigastric pain and hematuria. Imaging revealed circumferential thickening of the third portion of the duodenum, complicated by a rare duodenopyelic fistula and right renal obstruction. Endoscopic biopsy confirmed a poorly differentiated carcinoma of endometrial origin. Palliative management involved duodenal stenting, ureteral JJ stent placement, and systemic chemotherapy. This case highlights that duodenal metastasis from endometrial adenocarcinoma is often diagnosed late and carries a poor prognosis, necessitating a multimodal palliative approach aimed at symptom control.<\/jats:p>","DOI":"10.1177\/17455057261442701","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:28:13Z","timestamp":1779514093000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Duodenal metastasis from endometrial cancer: A rare metastatic site, a case report and literature review"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-3555","authenticated-orcid":false,"given":"Saida","family":"Sakhri","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8426-7804","authenticated-orcid":false,"given":"Eya","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethia","family":"Abidi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Salah Aza\u00efz Institute, Faculty of Medicine, University Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoldoz","family":"Houcine","sequence":"additional","affiliation":[{"name":"Department of Pathology, Salah Aza\u00efz Institute, Faculty of Medicine, University Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Ben","family":"Dhiab","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Salah Azaiez Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514010"},{"key":"e_1_3_2_4_2","article-title":"Duodenal recurrence of endometrial carcinoma: report of a rare metastatic site","volume":"5","author":"Pinheiro JL","year":"2021","unstructured":"Pinheiro JL, Marques M, Daniel C, et al. Duodenal recurrence of endometrial carcinoma: report of a rare metastatic site. J Surg Case Rep 2021; 5: rjab209.","journal-title":"J Surg Case Rep"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-223"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2018.1491311"},{"key":"e_1_3_2_7_2","first-page":"596","article-title":"A rare cause of intestinal bleeding: duodenal metastasis from endometrial cancer","volume":"109","author":"Leit\u00e3o C","year":"2017","unstructured":"Leit\u00e3o C, Caldeira A, Banhudo A. A rare cause of intestinal bleeding: duodenal metastasis from endometrial cancer. Rev Esp Enfermedades Dig 2017; 109: 596.","journal-title":"Rev Esp Enfermedades Dig"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14411"},{"key":"e_1_3_2_9_2","article-title":"Common cancer, puzzling presentation: a report of endometrial cancer presenting as an obstructive duodenal mass","volume":"6","author":"Ji S","year":"2020","unstructured":"Ji S, Deepanjana D, Elizabeth C, et al. Common cancer, puzzling presentation: a report of endometrial cancer presenting as an obstructive duodenal mass. J Case Rep Images Oncol 2020; 6: 100067Z10JS2020.","journal-title":"J Case Rep Images Oncol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-235051"},{"key":"e_1_3_2_11_2","article-title":"S2146 metastatic endometrial adenocarcinoma presenting as jaundice","volume":"118","author":"Lipshutz S","year":"2023","unstructured":"Lipshutz S, Mathur M, Chen WC, et al. S2146 metastatic endometrial adenocarcinoma presenting as jaundice. 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