{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:03:04Z","timestamp":1784379784338,"version":"3.55.0"},"reference-count":0,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    <jats:bold>What is this review about?<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>\n                    During the\n                    <jats:bold>menopausal transition<\/jats:bold>\n                    , women may experience disruptive symptoms like hot flashes during the day or night (night sweats) and have trouble sleeping. Many current treatments for hot flashes do not work for everyone because of potential side effects, health concerns, or individual needs and preferences.\n                  <\/jats:p>\n                  <jats:p>\n                    Elinzanetant is a hormone-free treatment for hot flashes linked to\n                    <jats:bold>menopause<\/jats:bold>\n                    . It works by targeting the source of hot flashes in the brain. This summary covers the results from four\n                    <jats:bold>randomized clinical trials<\/jats:bold>\n                    that tested elinzanetant in women: OASIS-1, OASIS-2, OASIS-3, and OASIS-4.\n                  <\/jats:p>\n                  <jats:p>\n                    The OASIS trials looked at how well elinzanetant works for women with menopause symptoms. OASIS-1, OASIS-2, and OASIS-3 included women with hot flashes from natural or surgical menopause. OASIS-4 focused on women who had hot flashes because they were taking\n                    <jats:bold>endocrine therapy<\/jats:bold>\n                    after initial treatment for breast cancer.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>What were the results?<\/jats:bold>\n                  <\/jats:p>\n                  <jats:p>The OASIS trials showed that elinzanetant rapidly reduces the number and severity of hot flashes experienced by women from natural or surgical menopause or due to endocrine therapy for breast cancer. Elinzanetant also improved their sleep and overall well-being. The side effects seen with elinzanetant were mainly mild and tolerable, the most common being headache, fatigue, and sleepiness.<\/jats:p>\n                  <jats:p>We use the term \u2018women\u2019 throughout for simplicity, but we recognize that menopause and its treatments may also be relevant to people who do not identify as women.<\/jats:p>","DOI":"10.1177\/17455057261462773","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:41:43Z","timestamp":1784047303000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Elinzanetant for the Treatment of Menopausal Hot Flashes: A Plain Language Review of the OASIS-1\u20134 Clinical Trial Results"],"prefix":"10.1177","volume":"22","author":[{"given":"JoAnn V.","family":"Pinkerton","sequence":"first","affiliation":[{"name":"University of Virginia Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella E.","family":"Nappi","sequence":"additional","affiliation":[{"name":"University of Pavia"},{"name":"IRCCS San Matteo Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio N.","family":"Soares","sequence":"additional","affiliation":[{"name":"Queen\u2019s University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Maki","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Centre Antoine Lacassagne"},{"name":"Advanced Breast Cancer (ABC) Global Alliance, Lisbon, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Donders","sequence":"additional","affiliation":[{"name":"Department of Clinical Research for Women"},{"name":"University of Antwerp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donal","family":"Brennan","sequence":"additional","affiliation":[{"name":"University College Dublin Gynecological Oncology Group"},{"name":"UCD School of Medicine"},{"name":"Mater Misericordiae University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Caetano","sequence":"additional","affiliation":[{"name":"Bayer CC AG, Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Seitz","sequence":"additional","affiliation":[{"name":"Bayer AG, Berlin, Germany;"},{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazanin","family":"Haseli-Mashhadi","sequence":"additional","affiliation":[{"name":"Bayer plc, Reading, England, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Haberland","sequence":"additional","affiliation":[{"name":"Bayer AG, Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Brown","sequence":"additional","affiliation":[{"name":"Women\u2019s advocate author, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Simon","sequence":"additional","affiliation":[{"name":"George Washington University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261462773","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17455057261462773","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261462773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T12:16:45Z","timestamp":1784377005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17455057261462773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":0,"alternative-id":["10.1177\/17455057261462773"],"URL":"https:\/\/doi.org\/10.1177\/17455057261462773","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"17455057261462773"}}