{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:36:26Z","timestamp":1792899386597,"version":"4.5.0"},"reference-count":68,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Dutch Research Council","award":["406.XS.24.01.016"],"award-info":[{"award-number":["406.XS.24.01.016"]}],"id":[{"id":"https:\/\/ror.org\/04jsz6e67","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Radboud Fonds","award":["SRF23007"],"award-info":[{"award-number":["SRF23007"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the role of oxytocin in the processing of positive emotional infant cues in mothers with PPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We therefore examined whether intranasal oxytocin influences postpartum mothers\u2019 processing of positive infant emotional cues, both visual (facial expressions) and auditory (laughter), and intended caregiving responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This double-blind randomized controlled crossover study included 45 mothers, with 3- to 9-month-old infants, who exhibited clinically relevant scores on the Edinburgh Postnatal Depression Scale, with 35 mothers fulfilling the criteria of a major depressive episode assessed with the SCID-5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mothers participated in two randomized counterbalanced sessions, receiving oxytocin and placebo in separate sessions with a washout period in between. During both sessions they completed an infant facial emotion recognition (FER) task and listened to infant laughter while physiological and self-report measures were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that oxytocin shifted response bias away from fear and toward sadness, while increasing accuracy for sad infant faces. This pattern suggests that oxytocin selectively reallocates attention from threat-related cues to those signaling infant need. Additionally, oxytocin elevated heart rate in response to infant laughter, indicating greater physiological engagement with positive cues, although self-reported affect and caregiving intentions were unaffected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that oxytocin may fine-tune perceptual and physiological responsiveness to emotionally salient infant signals rather than uniformly enhancing positive emotion recognition. The adaptive implications of this shift remain mixed: enhanced sensitivity to sadness may facilitate caregiving, yet excessive focus on distress could increase negative affect in vulnerable mothers. Oxytocin\u2019s effects thus appear emotion-specific, potentially providing mechanistic insight into altered maternal perception in postpartum depression. Future work should examine real-world caregiving behaviors and individual moderators, such as depression severity and trauma history, to clarify oxytocin\u2019s potential therapeutic relevance. Registration: The study is registered at the European Clinical Trial Registry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17455057261499422","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:35:03Z","timestamp":1792578903000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxytocin selectively enhances the recognition of infant sadness in postpartum depression"],"prefix":"10.1177","volume":"22","author":[{"given":"Merel","family":"van der Straaten","sequence":"first","affiliation":[{"name":"Radboud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mulders","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center"},{"name":"Donders Institute for Brain, Cognition and Behavior"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseriet","family":"Beijers","sequence":"additional","affiliation":[{"name":"Radboud University"},{"name":"Radboud University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira","family":"Tendolkar","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center"},{"name":"Donders Institute for Brain, Cognition and Behavior"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike","family":"Cima","sequence":"additional","affiliation":[{"name":"Radboud University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-7939","authenticated-orcid":false,"given":"Madelon M. E.","family":"Riem","sequence":"additional","affiliation":[{"name":"Radboud University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.16121"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000183597.31630.db"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/09540269609037817"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-011-0223-8"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/14616734.2018.1430839"},{"key":"e_1_3_8_7_2","volume-title":"Patterns of attachment","author":"Ainsworth MD","year":"1978","unstructured":"Ainsworth MD, Blehar M, Waters E, et al. Patterns of attachment. Erlbaum, 1978."},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.04.015"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-016-0643-3"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104793"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.07.052"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2016.0213"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-016-0642-7"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2009.10.005"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2010.03.002"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327078IN0204_06"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/02699931.2014.977849"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.04.005"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.102.3.358"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-1-10"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131305"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2019.1581331"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/imhj.10092"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.143916"},{"key":"e_1_3_8_25_2","article-title":"Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying","author":"Riem MME","year":"2010","unstructured":"Riem MME, Pieper S, Out D, et al. Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. Soc Cogn Affect Neurosci 2010.","journal-title":"Soc Cogn Affect Neurosci"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq091"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.02.045"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0014943"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.313"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/15295192.2020.1715686"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.103"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0036986"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1978.tb01337.x"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2134(98)00055-6"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1037\/fam0001128"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110098"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2025.107530"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.11.062"},{"key":"e_1_3_8_39_2","first-page":"1","article-title":"Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression","author":"Lindley Baron-Cohen K","year":"2024","unstructured":"Lindley Baron-Cohen K, Fearon P, Meins E, et al. Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. Dev Psychopathol 2024: 1\u201312.","journal-title":"Dev Psychopathol"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00759"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.10.005"},{"key":"e_1_3_8_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.22245"},{"key":"e_1_3_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.010"},{"key":"e_1_3_8_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781118625392.wbecp351"},{"key":"e_1_3_8_45_2","doi-asserted-by":"crossref","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 Statement: updated guideline for reporting randomised trials","volume":"388","author":"Hopewell S","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS, et al. CONSORT 2025 Statement: updated guideline for reporting randomised trials. BMJ 2025; 388: e081123. https:\/\/doi.org\/10.1136\/bmj-2024-081123","journal-title":"BMJ"},{"key":"e_1_3_8_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00864-7"},{"key":"e_1_3_8_47_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.6.782"},{"key":"e_1_3_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(92)90041-4"},{"key":"e_1_3_8_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/02646838.2016.1141346"},{"key":"e_1_3_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.10.021"},{"key":"e_1_3_8_51_2","doi-asserted-by":"publisher","DOI":"10.1348\/0144665031752934"},{"key":"e_1_3_8_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2019.02.003"},{"key":"e_1_3_8_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-018-3808-0"},{"key":"e_1_3_8_54_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3303-9"},{"key":"e_1_3_8_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18030869"},{"key":"e_1_3_8_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.07.024"},{"key":"e_1_3_8_57_2","doi-asserted-by":"publisher","DOI":"10.1080\/03091902.2019.1640306"},{"key":"e_1_3_8_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/10253890.2022.2054697"},{"key":"e_1_3_8_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.04.015"},{"key":"e_1_3_8_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.025"},{"key":"e_1_3_8_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.123"},{"key":"e_1_3_8_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2020.101934"},{"key":"e_1_3_8_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.07.020"},{"key":"e_1_3_8_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(98)00100-7"},{"key":"e_1_3_8_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.infbeh.2008.10.005"},{"key":"e_1_3_8_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq091"},{"key":"e_1_3_8_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-02898-1"},{"key":"e_1_3_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2021.101985"},{"key":"e_1_3_8_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2025.106257"}],"container-title":["Women's Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261499422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17455057261499422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17455057261499422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:24:17Z","timestamp":1792898657000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17455057261499422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"alternative-id":["10.1177\/17455057261499422"],"URL":"https:\/\/doi.org\/10.1177\/17455057261499422","relation":{},"ISSN":["1745-5057","1745-5065"],"issn-type":[{"value":"1745-5057","type":"print"},{"value":"1745-5065","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"article-number":"17455057261499422"}}