{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:06:49Z","timestamp":1793869609927,"version":"4.6.1"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Womens Health (Lond Engl)"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    Cervical cancer, the third most common cancer in women, is caused in nearly all cases by a persistent infection with high-risk types of the human papillomavirus. Although human papillomavirus infections are 80%\u201390% transient and disappear spontaneously within 24\u2009months, human papillomavirus infections that remain are at risk of developing cervical lesions. Different therapeutical approaches have been tested to promote the regression of low-grade lesions or prevent progression. They include the application of 5-fluorouracil, curcumin, imiquimod, interferons, Vitamin D, and others. Also, the effect of probiotics and vaginal therapy with carboxy-methyl-beta glucan was assessed. Review of the literature and presentation of the last study data are presented. Clearance of high-risk human papillomavirus seemed to be promoted by treatment with a new vaginal gel containing a highly disperse SiO\n                    <jats:sub>2<\/jats:sub>\n                    and an anti-oxidative combination of citric acid and sodium. This gel showed, after 6\u2009months, an improvement of cytological Pap findings (ASC-US, LSIL, ASC-H, or HSIL) in 80.9% of the participants. Similarly, there was a clearing of hr-human papillomavirus in 53% of cases after 3\u2009months of gel administration. The percentage increased slightly in the non-treated control group from 78.3% at baseline to 83% after 3\u2009months. The percentage of patients who were tested positive for p16\/Ki67 reduced from 75% at baseline to 5.3% in the treatment group after 6\u2009months, while the percentage decreased only slightly in the non-treated group (baseline: 91.5%; 6\u2009months: 75.2%). The examined vaginal gel may support the healing of conspicuous cytological findings (ASC-US, LSIL, ASC-H, or HSIL) and clearance of hr-human papillomavirus positive results.\n                  <\/jats:p>","DOI":"10.1177\/17455065211020702","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T02:52:27Z","timestamp":1623034347000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite"],"prefix":"10.1177","volume":"17","author":[{"given":"Johannes","family":"Huber","sequence":"first","affiliation":[{"name":"Universit\u00e4tsfrauenklinik Wien, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mueller","sequence":"additional","affiliation":[{"name":"Exeltis Germany GmbH, Ismaning, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Sailer","sequence":"additional","affiliation":[{"name":"Exeltis Germany GmbH, Ismaning, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-2847","authenticated-orcid":false,"given":"Pedro-Antonio","family":"Regidor","sequence":"additional","affiliation":[{"name":"Exeltis Germany, Ismaning, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"key":"bibr1-17455065211020702","unstructured":"Bruni L, Albero G, Serrano B, et al. 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