{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:03:39Z","timestamp":1777943019545,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2016,6]]},"abstract":"\n Rationale<\/jats:title>\n A key objective of A Very Early Rehabilitation Trial is to determine if the intervention, very early mobilisation following stroke, is cost-effective. Resource use data were collected to enable an economic evaluation to be undertaken and a plan for the main economic analyses was written prior to the completion of follow up data collection.<\/jats:p>\n <\/jats:sec>\n \n Aim and hypothesis<\/jats:title>\n To report methods used to collect resource use data, pre-specify the main economic evaluation analyses and report other intended exploratory analyses of resource use data.<\/jats:p>\n <\/jats:sec>\n \n Sample size estimates<\/jats:title>\n Recruitment to the trial has been completed. A total of 2,104 participants from 56 stroke units across three geographic regions participated in the trial.<\/jats:p>\n <\/jats:sec>\n \n Methods and design<\/jats:title>\n Resource use data were collected prospectively alongside the trial using standardised tools. The primary economic evaluation method is a cost-effectiveness analysis to compare resource use over 12 months with health outcomes of the intervention measured against a usual care comparator. A cost-utility analysis is also intended.<\/jats:p>\n <\/jats:sec>\n \n Study outcome<\/jats:title>\n The primary outcome in the cost-effectiveness analysis will be favourable outcome (modified Rankin Scale score 0-2) at 12 months. Cost-utility analysis will use health-related quality of life, reported as quality-adjusted life years gained over a 12 month period, as measured by the modified Rankin Scale and the Assessment of Quality of Life.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Outcomes of the economic evaluation analysis will inform the cost-effectiveness of very early mobilisation following stroke when compared to usual care. The exploratory analysis will report patterns of resource use in the first year following stroke.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/1747493016632254","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T22:43:26Z","timestamp":1456958606000},"page":"492-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Economic Evaluation Plan (EEP) for A Very Early Rehabilitation Trial (AVERT): An international trial to compare the costs and cost-effectiveness of commencing out of bed standing and walking training (very early mobilization) within 24\u2009h of stroke onset with usual stroke unit care"],"prefix":"10.1177","volume":"11","author":[{"given":"Lauren","family":"Sheppard","sequence":"first","affiliation":[{"name":"Deakin Health Economics, Centre for Population Health Research, Deakin University, Geelong, Australia"},{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Dewey","sequence":"additional","affiliation":[{"name":"Eastern Health Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M","family":"Collier","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Ellery","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Churilov","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiu","family":"Tay-Teo","sequence":"additional","affiliation":[{"name":"Deakin Health Economics, Centre for Population Health Research, Deakin University, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing, University of Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marj","family":"Moodie","sequence":"additional","affiliation":[{"name":"Deakin Health Economics, Centre for Population Health Research, Deakin University, Geelong, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of The AVERT Trial 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