{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:04:57Z","timestamp":1783544697219,"version":"3.55.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Coma is associated with poor outcome in patients with basilar artery occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to assess whether the posterior circulation Acute Stroke Prognosis Early CT Score and the Pons-Midbrain Index applied to CT angiography source images predict the outcome of comatose patients in the Basilar Artery International Cooperation Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Basilar Artery International Cooperation Study was a prospective, observational registry of patients with acute basilar artery occlusion with 48 recruiting centers worldwide. We applied posterior circulation Acute Stroke Prognosis Early CT Score and Pons-Midbrain Index to CT angiography source images of Basilar Artery International Cooperation Study patients who presented with coma. We calculated adjusted risk ratios to assess the association of dichotomized posterior circulation Acute Stroke Prognosis Early CT Score (\u22658 vs. &lt;8) and Pons-Midbrain Index (&lt;3 vs. \u22653) with mortality and favourable outcome (modified Rankin Scale score 0\u20133) at one month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 619 patients in the Basilar Artery International Cooperation Study registry, CT angiography source images were available for review in 158 patients. Among these, 78 patients (49%) presented with coma. Compared to non-comatose patients, comatose patients were more likely to die (risk ratios 2.34; CI 95% 1.56\u20133.52) and less likely to have a favourable outcome (risk ratios 0.44; CI 95% 0.24\u20130.80). Among comatose patients, a Pons-Midbrain Index\u2009&lt;\u20093 was related to reduced mortality (adjusted RR 0.66; 95% CI 0.46\u20130.96), but not to favourable outcome (adjusted RR 1.19; 95% CI 0.39\u20133.62). Posterior circulation Acute Stroke Prognosis Early CT Score dichotomized at\u2009\u2265\u20098 vs. &lt;8 was not significantly associated with death (adjusted RR 0.70; 95% CI 0.46\u20131.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In comatose patients with basilar artery occlusion, the extent of brainstem ischemia appears to be related to mortality but not to favourable outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493016669886","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T21:31:08Z","timestamp":1475530268000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["CT-angiography source images indicate less fatal outcome despite coma of patients in the Basilar Artery International Cooperation Study"],"prefix":"10.1177","volume":"12","author":[{"given":"Lars P","family":"Pallesen","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Khomenko","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanuel","family":"Dzialowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Elblandklinikum Meissen, Meissen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Barlinn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Barlinn","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Zerna","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"},{"name":"Calgary Stroke Program, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik JRJ","family":"van der Hoeven","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Jaap","family":"Kapelle","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Vaudois, Centre C\u00e9r\u00e9brovasculaire, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Bodechtel","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Demchuk","sequence":"additional","affiliation":[{"name":"Calgary Stroke Program, University of Calgary, Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Schonewille","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands"},{"name":"Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Puetz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Technology Dresden, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the BASICS-Study 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