{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:27:11Z","timestamp":1778599631185,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>A pre-specified country analysis of subjects from the Philippines in the CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) Study showed significantly improved functional and neurological outcomes on MLC601 at month (M) 3. We aimed to assess these effects on long-term functional recovery in the Filipino cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The CHIMES-E (extension) Study evaluated subjects who completed three months of randomized placebo-controlled treatment in CHIMES up to two years. Blinding of treatment allocation was maintained and all subjects received standard stroke care and rehabilitation. Modified Rankin Score (mRS) and Barthel Index (BI) were assessed in-person at M3 and by telephone at M6, M12, M18, M24. Odds ratios (OR) with corresponding 95% confidence intervals (CI) for functional recovery using ordinal analysis of mRS and for achieving functional independence (mRS 0-1 or BI\u2009\u2265\u200995) at each time point were calculated, adjusting for age, sex, baseline National Institute of Health Stroke Scale (NIHSS), onset-to-treatment time (OTT) and pre-stroke mRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 378 subjects (MLC601 192, placebo 186) included in CHIMES-E from the Philippines (mean age 60.2\u2009\u00b1\u200911.1) had more women ( p\u2009&lt;\u20090.001), worse baseline NIHSS ( p\u2009&lt;\u20090.001) and longer onset to treatment time ( p\u2009=\u20090.002) compared to other countries. Baseline characteristics were similar between treatment groups. The treatment effect of MLC601 seen at M3 peaked at M6 with OR for mRS shift of 1.53 (95% CI 1.05\u20132.22), mRS dichotomy 0\u20131 of 1.77 (95% CI 1.10\u20132.83), and BI\u2009\u2265\u200995 of 1.87 (95% CI 1.16\u20133.02). The beneficial effect persisted up to M24.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The beneficial effect of MLC601 seen at M3 in the Filipino cohort is durable up to two years after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493016676615","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T21:49:13Z","timestamp":1477518553000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Durability of the beneficial effect of MLC601 (NeuroAiD\u2122) on functional recovery among stroke patients from the Philippines in the CHIMES and CHIMES-E studies"],"prefix":"10.1177","volume":"12","author":[{"given":"Jose C","family":"Navarro","sequence":"first","affiliation":[{"name":"University of Santo Tomas Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher LH","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Clinical Research Centre, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun F","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herminigildo H","family":"Gan","sequence":"additional","affiliation":[{"name":"Jose Reyes Memorial Medical Center, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabelle Y","family":"Lao","sequence":"additional","affiliation":[{"name":"Davao Medical School Foundation Hospital, San Pedro Hospital, Davao City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Alejandro C","family":"Baroque","sequence":"additional","affiliation":[{"name":"University of Santo Tomas Hospital, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Harold B","family":"Hiyadan","sequence":"additional","affiliation":[{"name":"Baguio General Hospital and Medical Center, Baguio City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos L","family":"Chua","sequence":"additional","affiliation":[{"name":"Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma Cristina","family":"San Jose","sequence":"additional","affiliation":[{"name":"Philippine General Hospital, University of the Philippines Manila, Manila, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M","family":"Advincula","sequence":"additional","affiliation":[{"name":"West Visayas State University Medical Center, Iloilo City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[{"name":"Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the CHIMES and CHIMES-E Study 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