{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:06:13Z","timestamp":1780506373351,"version":"3.54.1"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although acute central retinal artery occlusion is as a stroke in the carotid territory (retinal artery), its management remains controversial. The aim of this study was to assess the feasibility and safety of intravenous thrombolysis delivered within 6\u2009h of central retinal artery occlusion in French stroke units.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of patients treated with intravenous alteplase (recombinant tissue-plasminogen activator), based on stroke units thrombolysis registers from June 2005 to June 2015, and we selected those who had acute central retinal artery occlusion. The feasibility was assessed by the ratio of patients that had received intravenous alteplase within 6\u2009h after central retinal artery occlusion onset among those who had been admitted to the same hospital for acute central retinal artery occlusion. All adverse events were documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty patients were included. Visual acuity before treatment was limited to \u201chand motion\u201d, or worse, in 90% of the cases. The mean onset-to-needle time was 273\u2009min. The individuals treated with intravenous alteplase for central retinal artery occlusion represented 10.2% of all of the patients hospitalized for central retinal artery occlusion in 2013 and 2014. We observed one occurrence of major bleeding, a symptomatic intracerebral hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When applied early on, intravenous thrombolysis appears to be feasible and safe, provided that contraindications are given due consideration. Whether intravenous thrombolysis is more effective than conservative therapy remains to be determined. In order to conduct a well-designed prospective randomized control trial, an organized network should be in place.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493016687578","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T09:20:11Z","timestamp":1483953611000},"page":"720-723","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe"],"prefix":"10.1177","volume":"12","author":[{"given":"C\u00e9cile","family":"Pr\u00e9terre","sequence":"first","affiliation":[{"name":"Department of Neurology, CHU de Nantes \u2013 La\u00ebnnec Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Godeneche","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHG La Rochelle-R\u00e9-Aunis, La Rochelle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vandamme","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHG La Rochelle-R\u00e9-Aunis, La Rochelle, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ronzi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU Pontchaillou, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lamy","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Breuilly","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHIC de Cornouailles, Quimper, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Urbanczyk","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHD de Vend\u00e9e Les Oudairies, La Roche sur Yon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHRU de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lebranchu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, CHU de Nantes \u2013 H\u00f4tel Dieu, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Sevin-Allouet","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU de Nantes \u2013 La\u00ebnnec Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Guillon","sequence":"additional","affiliation":[{"name":"Department of Neurology, CHU de Nantes \u2013 La\u00ebnnec Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"bibr1-1747493016687578","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.10.1377"},{"key":"bibr2-1747493016687578","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e31814b1f66"},{"key":"bibr3-1747493016687578","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1001\/archopht.120.9.1234","volume":"120","author":"Kattah JC","year":"2002","journal-title":"Arch 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