{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:04:31Z","timestamp":1777943071870,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"MRC","award":["G0600986"],"award-info":[{"award-number":["G0600986"]}]},{"name":"EU","award":["EUSTROKE Grant Health-F2-2008-2022131"],"award-info":[{"award-number":["EUSTROKE Grant Health-F2-2008-2022131"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Je 598\/1-1"],"award-info":[{"award-number":["Je 598\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Mapping the hypoxic brain in acute ischemic stroke has considerable potential for both diagnosis and treatment monitoring. PET using\n                      <jats:sup>18<\/jats:sup>\n                      F-fluoro-misonidazole (FMISO) is the reference method; however, it lacks clinical accessibility and involves radiation exposure. MR-based T2\u2032 mapping may identify tissue hypoxia and holds clinical potential. However, its validation against FMISO imaging is lacking. Here we implemented back-to-back FMISO-PET and T2\u2032 MR in rodents subjected to acute middle cerebral artery occlusion. For direct clinical relevance, regions of interest delineating reduced T2\u2032 signal areas were manually drawn.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wistar rats were subjected to filament middle cerebral artery occlusion, immediately followed by intravenous FMISO injection. Multi-echo T2 and T2* sequences were acquired twice during FMISO brain uptake, interleaved with diffusion-weighted imaging. Perfusion-weighted MR was also acquired whenever feasible. Immediately following MR, PET data reflecting the history of FMISO brain uptake during MR acquisition were acquired. T2\u2032 maps were generated voxel-wise from T2 and T2*. Two raters independently drew T2\u2032 lesion regions of interest. FMISO uptake and perfusion data were obtained within T2\u2032 consensus regions of interest, and their overlap with the automatically generated FMISO lesion and apparent diffusion coefficient lesion regions of interest was computed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As predicted, consensus T2\u2032 lesion regions of interest exhibited high FMISO uptake as well as substantial overlap with the FMISO lesion and significant hypoperfusion, but only small overlap with the apparent diffusion coefficient lesion. Overlap of the T2\u2032 lesion regions of interest between the two raters was \u223c50%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides formal validation of T2\u2032 to map non-core hypoxic tissue in acute stroke. T2\u2032 lesion delineation reproducibility was suboptimal, reflecting unclear lesion borders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493017706221","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T06:36:07Z","timestamp":1495175767000},"page":"752-760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain hypoxia mapping in acute stroke: Back-to-back T2\u2032 MR versus\n                    <sup>18<\/sup>\n                    F-fluoromisonidazole PET in rodents"],"prefix":"10.1177","volume":"12","author":[{"given":"Ulf","family":"Jensen-Kondering","sequence":"first","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"},{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"},{"name":"Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roido","family":"Manavaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohail","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J","family":"Sawiak","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T Adrian","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D","family":"Fryer","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin I","family":"Aigbirhio","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Williamson","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Baron","sequence":"additional","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"},{"name":"INSERM U894, Universit\u00e9 Paris Descartes, H\u00f4pital Sainte-Anne, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"bibr1-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1186\/cc5973"},{"key":"bibr2-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70545-2"},{"key":"bibr3-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.485938"},{"key":"bibr4-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600405"},{"key":"bibr5-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000226908.93295.9d"},{"key":"bibr6-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.06.102"},{"key":"bibr7-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-010-0371-4"},{"key":"bibr8-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.02.005"},{"key":"bibr9-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-013-2581-x"},{"key":"bibr10-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20265"},{"key":"bibr11-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1056"},{"key":"bibr12-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000094422.74023.FF"},{"key":"bibr13-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh162"},{"key":"bibr14-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200008)48:2<228::AID-ANA13>3.0.CO;2-B"},{"key":"bibr15-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1617"},{"key":"bibr16-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12180"},{"key":"bibr17-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.632455"},{"key":"bibr18-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2839"},{"key":"bibr19-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006530"},{"key":"bibr20-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000226738.97426.6f"},{"key":"bibr21-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199912)42:6<1027::AID-MRM6>3.0.CO;2-#"},{"key":"bibr22-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.11.023"},{"key":"bibr23-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.646109"},{"key":"bibr24-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/318346"},{"key":"bibr25-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.10.014"},{"key":"bibr26-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10803"},{"key":"bibr27-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400213"},{"key":"bibr28-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161408"},{"key":"bibr29-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.120"},{"key":"bibr30-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.56"},{"key":"bibr31-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199611000-00012"},{"key":"bibr32-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12147"},{"key":"bibr33-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.8.1958"},{"key":"bibr34-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199705000-00009"},{"key":"bibr35-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200009000-00009"},{"key":"bibr36-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15622466"},{"key":"bibr37-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-927183"},{"key":"bibr38-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2483071602"},{"key":"bibr39-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10523"},{"key":"bibr40-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340607"},{"key":"bibr41-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70192-2"},{"key":"bibr42-1747493017706221","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.158"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493017706221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1747493017706221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493017706221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:15:13Z","timestamp":1777706113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1747493017706221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1177\/1747493017706221"],"URL":"https:\/\/doi.org\/10.1177\/1747493017706221","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}