{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:04:48Z","timestamp":1777943088208,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New evidence regarding stroke prevention in atrial fibrillation has been published. Implementing knowledge into clinical practice remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate oral anticoagulants in stroke patients documented in a nationwide registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The database is an obligatory federal-state-wide hospital-based registry that covers more than 95% of all ischemic strokes, transient ischemic attacks and intracerebral hemorrhages in a community of more than six million inhabitants (Hesse\/Germany). We analyzed oral anticoagulants prescribed on discharge in patients with stroke or transient ischemic attack during 2006\u20132015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 2006 to 2015, we annually selected median 20,895 patients. From 2006 to 2015, the proportion of patients treated with oral anticoagulants increased (9.8% to 24%). The annual proportion of patients with atrial fibrillation remained constant (median: 23%). In atrial fibrillation patients treated with oral anticoagulants, the age increased (median 2008\/2009: 76.9 years vs. 2014\/2015 79.4 years). The percentage of treated individuals in atrial fibrillation increased dramatically (2006: 30.1% to 2015: 74.5%); in 2015, 30.8% of these patients received vitamin K antagonists and 70.2% new oral anticoagulants. Independent factors associated with new oral anticoagulants therapy were a previous medication with new oral anticoagulants and a treatment on stroke unit. Between new oral anticoagulants- and vitamin K antagonists-treated patients (2015), no differences in age were noted (both mean: 79.4 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The new oral anticoagulants availability enhanced a general trend treating more target patients with oral anticoagulants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493017733928","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T09:11:54Z","timestamp":1506503514000},"page":"308-312","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["One decade of oral anticoagulation in stroke patients: Results from a large country-wide hospital-based registry"],"prefix":"10.1177","volume":"13","author":[{"given":"Christian","family":"Tanislav","sequence":"first","affiliation":[{"name":"Neurology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Allend\u00f6rfer","sequence":"additional","affiliation":[{"name":"Neurology, Bad Salzhausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-8842","authenticated-orcid":false,"given":"Waltraud","family":"Pfeilschifter","sequence":"additional","affiliation":[{"name":"Neurology, Goethe University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Fuest","sequence":"additional","affiliation":[{"name":"Neurology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Stein","sequence":"additional","affiliation":[{"name":"Neurosurgery, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Meyer","sequence":"additional","affiliation":[{"name":"Neurology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Reuter","sequence":"additional","affiliation":[{"name":"Neurology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kaps","sequence":"additional","affiliation":[{"name":"Neurology, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Misselwitz","sequence":"additional","affiliation":[{"name":"Institute of quality assurance Hesse, Eschborn\/Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"bibr1-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl015"},{"key":"bibr2-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.08.012"},{"key":"bibr3-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92358-Z"},{"key":"bibr4-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.08.042"},{"key":"bibr5-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1159\/000371574"},{"key":"bibr6-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-014-0195-y"},{"key":"bibr7-1747493017733928","doi-asserted-by":"crossref","unstructured":"Connolly SJ, Ezekowitz MD, Yusuf S, et\u00a0al. Dabigatran versus warfarin in patients with atrial fibrillation.\n                      N Engl J Med\n                      200917; 361: 1139\u20131151.","DOI":"10.1056\/NEJMoa0905561"},{"key":"bibr8-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"bibr9-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70042-X"},{"key":"bibr10-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"bibr11-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.008"},{"key":"bibr12-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.157248"},{"key":"bibr13-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12452"},{"key":"bibr14-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.12.008"},{"key":"bibr15-1747493017733928","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32832e4954"},{"key":"bibr16-1747493017733928","first-page":"607","volume":"108","author":"Stolz E","year":"2011","journal-title":"Dtsch Arztebl Int"},{"key":"bibr17-1747493017733928","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67024-9"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493017733928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1747493017733928","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493017733928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:15:39Z","timestamp":1777706139000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1747493017733928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1177\/1747493017733928"],"URL":"https:\/\/doi.org\/10.1177\/1747493017733928","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]}}}