{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:12Z","timestamp":1787019312135,"version":"build-2736575974"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large vessel disease stroke subtype carries the highest risk of early recurrent stroke. In this study we aim to look at the association between impaired perfusion and early stroke recurrence in patients with intracranial atherosclerotic disease or total cervical carotid occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a retrospective study from a comprehensive stroke center where we included consecutive patients 18 years or older with intracranial atherosclerotic disease or total cervical carotid occlusion admitted with a diagnosis of ischemic stroke within 24\u2009h from symptom onset with National Institute Health Stroke Scale\u2009&lt;\u200915, between 1 December 2016 and 30 June 2017. Patients with (1) evidence of\u2009\u2265\u200950% stenosis of a large intracranial artery or total carotid artery occlusion, (2) symptoms referable to the territory of the affected artery, and (3) perfusion imaging data using the RAPID processing software were included. The primary predictor was unfavorable perfusion imaging defined as T\n                      <jats:sub>max<\/jats:sub>\n                      \u2009&gt;\u20096\u2009s mismatch volume (penumbra volume\u2013infarct volume) of 15\u2009ml or more. The outcome was recurrent cerebrovascular events at 90 days defined as worsening or new neurological symptoms in the absence of a nonvascular cause attributable to the decline, or new infarct or infarct extension in the territory of the affected artery. We used Cox proportional hazards models to determine the association between impaired perfusion and recurrent cerebrovascular events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty-two patients met our inclusion criteria; mean age 66.4\u2009\u00b1\u200913.1 years, 64.5% male (40\/62) and 50.0% (31\/62) with intracranial atherosclerotic disease. When compared to patients with favorable perfusion pattern, patients with unfavorable perfusion pattern were more likely to have recurrent cerebrovascular events (55.6% (10\/18) versus 9.1% (4\/44), p\u2009&lt;\u20090.001). This association persisted after adjusting for potential confounders (adjusted hazard ratio 10.44, 95% confidence interval 2.30\u201347.42, p\u2009=\u20090.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perfusion mismatch predicts recurrent cerebrovascular events in patients with ischemic stroke due to intracranial atherosclerotic disease or total cervical carotid occlusion. Studies are needed to determine the utility of revascularization strategies in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493018764075","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T04:11:07Z","timestamp":1520223067000},"page":"592-599","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Perfusion imaging and recurrent cerebrovascular events in intracranial atherosclerotic disease or carotid occlusion"],"prefix":"10.1177","volume":"13","author":[{"given":"Daniel C","family":"Sacchetti","sequence":"first","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna M","family":"Cutting","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A","family":"McTaggart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, USA"},{"name":"Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-0228","authenticated-orcid":false,"given":"Andrew D","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Hemendinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Mac Grory","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Siket","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"},{"name":"Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K","family":"Rostanski","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York University School of Medicine, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"Department of Neurology, Northwestern University, Evanston, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua Z","family":"Willey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph S","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell SV","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University Medical Center, New York, USA"},{"name":"The Mailman School of Public Health, Columbia University, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Cincinnati, Cincinnati, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Furie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh V","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, USA"},{"name":"Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, USA"},{"name":"Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-1004","authenticated-orcid":false,"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, 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