{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:36:30Z","timestamp":1786559790943,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T00:00:00Z","timestamp":1537228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"John Hunter Hospital","award":["Charitable Trust Grant"],"award-info":[{"award-number":["Charitable Trust Grant"]}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["Future Leaders Fellowship"],"award-info":[{"award-number":["Future Leaders Fellowship"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000930","name":"National Stroke Foundation","doi-asserted-by":"publisher","award":["Seeding Grant"],"award-info":[{"award-number":["Seeding Grant"]}],"id":[{"id":"10.13039\/501100000930","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Senior Research Fellowship"],"award-info":[{"award-number":["Senior Research Fellowship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>People with stroke sit for long periods each day, which may compromise blood glucose control and increase risk of recurrent stroke. Studies in other populations have found regular activity breaks have a significant immediate (within-day) positive effect on glucose metabolism. We examined the effects of breaking up uninterrupted sitting with frequent, short bouts of light-intensity physical activity in people with stroke on post-prandial plasma glucose and insulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized within-participant crossover trial. We included people between 3 months and 10 years post-stroke, ambulant with minimal assistance and not taking diabetic medication other than metformin. The three experimental conditions (completed in random order) were: sitting for 8 h uninterrupted, sitting with 3 min bouts of light-intensity exercise while standing every 30 min, or sitting with 3 min of walking every 30 min. Meals were standardized and bloods were collected half- to one-hourly via an intravenous cannula.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 19 participants (9 female, mean [SD] age 68.2 [10.2]) completed the trial. The majority ( n\u2009=\u200912, 63%) had mild stroke symptoms (National Institutes of Stroke Scale score 0\u201313). There was no significant effect of experimental condition on glucose (mean [SD] positive incremental area [+iAUC] mmol\u00b7L\u00b7h-1 under the curve during sitting 42.3 [29.5], standing 47.4 [23.1], walking 44.6 [26.5], p\u2009=\u20090.563) or insulin (mean\u2009+\u2009iAUC pmol\u00b7L\u00b7h-1 sitting 14,161 [7,560], standing 14,043 [8,312], walking 14,008 [8,269], p\u2009=\u20090.987).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frequent, short bouts of light-intensity physical activity did not have a significant effect on post-prandial plasma glucose and insulin in this sample of people with stroke. Further studies are needed to identify strategies that improve inactivity-related glucose metabolism after stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493018801222","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T10:08:45Z","timestamp":1537265325000},"page":"921-931","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Breaking up sitting time after stroke (BUST-stroke)"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-7927","authenticated-orcid":false,"given":"Coralie","family":"English","sequence":"first","affiliation":[{"name":"School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia"},{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Janssen","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia"},{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"},{"name":"Hunter Stroke Services, Hunter New England Local Health District, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Crowfoot","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia"},{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Callister","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, and Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee","family":"Dunn","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Pharmacy, and Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mackie","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia"},{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Oldmeadow","sequence":"additional","affiliation":[{"name":"Clinical Research Design, Information Technology and Statistical Support (CReDITSS), Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin K","family":"Ong","sequence":"additional","affiliation":[{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"},{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrin","family":"Palazzi","sequence":"additional","affiliation":[{"name":"Clinical Research Design, Information Technology and Statistical Support (CReDITSS), Hunter Medical Research Institute, New Lambton Heights, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J","family":"Patterson","sequence":"additional","affiliation":[{"name":"School of Health Sciences, University of Newcastle, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J","family":"Spratt","sequence":"additional","affiliation":[{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"},{"name":"Department of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Rohan","family":"Walker","sequence":"additional","affiliation":[{"name":"Centre for Research Excellence in Stroke Recovery and Rehabilitation, Florey Institute of Neuroscience, Melboure, Australia"},{"name":"School of Biomedical Sciences and Pharmacy and the Priority Research Centre for Stroke 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