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One target is mammalian target of rapamycin (mTOR), a serine\/threonine kinase regulating cell proliferation, cell survival, protein synthesis, and autophagy. Animal studies investigating the effect of rapamycin on mTOR inhibition following cerebral ischemia have shown conflicting results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To conduct a systematic review and meta-analysis evaluating the effectiveness of rapamycin in reducing infarct volume in animal models of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary of review<\/jats:title>\n                    <jats:p>Our search identified 328 publications. Seventeen publications met inclusion criteria (52 comparisons: 30 reported infarct size and 22 reported neurobehavioral score). Study quality was modest (median 4 of 9) with no evidence of publication bias. The point estimate for the effect of rapamycin was a 21.6% (95% CI, 7.6%\u201335.7% p\u2009&lt;\u20090.01) improvement in infarct volume and 30.5% (95% CI 17.2%\u201343.8%, p\u2009&lt;\u20090.0001) improvement in neuroscores. Effect sizes were greatest in studies using lower doses of rapamycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low-dose rapamycin treatment may be an effective therapeutic option for stroke. Modest study quality means there is a potential risk of bias. We recommend further high-quality preclinical studies on rapamycin in stroke before progressing to clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493018816503","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T10:01:15Z","timestamp":1543485675000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-7588","authenticated-orcid":false,"given":"Daniel J","family":"Beard","sequence":"first","affiliation":[{"name":"Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, 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