{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:31Z","timestamp":1790232571870,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Departamento de Ci\u00eancia e Tecnologia (DECIT), Minist\u00e9rio da Sa\u0171de do Brasil, Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f6gico"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>RESILIENT is a prospective, multicenter, randomized phase III trial to test the safety, efficacy, and cost-effectiveness of mechanical thrombectomy as compared to medical treatment alone in patients treated under the less than ideal conditions typically found in the public healthcare system of a developing country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects must fulfill the following main inclusion criteria: symptom onset \u22648\u2009h, age \u226518 years, baseline NIHSS \u22658, evidence of intracranial ICA or proximal MCA (M1 segment) occlusion, ASPECTS \u22656 on CT or &gt;5 on DWI-MRI and be either ineligible for or unresponsive to intravenous alteplase. The primary end-point is the distribution of disability levels (on the modified Rankin Scale, mRS) at 90 days under the intention-to-treat principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Randomization<\/jats:title>\n                    <jats:p>Randomization is performed under a minimization process using age, baseline NIHSS, intravenous alteplase use, occlusion site and center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The trial is designed with an expectation of a 10% difference in the proportion of favorable outcome (mRS 0\u20132 at 90 days) common odds ratio of 1.615.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Projected sample size is 690 subjects with pre-planned interim analyses at 174, 346, and 518 subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Secondary outcomes<\/jats:title>\n                    <jats:p>Secondary end-points include: 90-day functional independence (mRS \u22642), mRS shift stratified for treatment with IV rt-PA at 90 days, infarct volume on 24\u2009h CT or MRI, early dramatic response (NIHSS 0\u20132 or improvement \u22658 points) at 24\u2009h, vessel recanalization evaluated by CTA or MRA at 24\u2009h, and the post-procedure rate of successful reperfusion (defined as a modified Treatment in Cerebral Infarction 2b or greater). Safety variables are mortality at 90 days, symptomatic intracranial hemorrhage at 24\u2009h and procedure-related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493019890700","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T01:18:07Z","timestamp":1575335887000},"page":"100-109","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Randomization of endovascular treatment with stent-retriever and\/or thromboaspiration versus best medical therapy in acute ischemic stroke due to large vessel occlusion trial: Rationale and design"],"prefix":"10.1177","volume":"16","author":[{"given":"Raul G","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Neurology, Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, Emory University School of Medicine, Atlanta, GA, 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