{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:06:19Z","timestamp":1777943179634,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA\u201417CPOST33680102"],"award-info":[{"award-number":["AHA\u201417CPOST33680102"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS059775"],"award-info":[{"award-number":["R01NS059775"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS063925"],"award-info":[{"award-number":["R01NS063925"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082285"],"award-info":[{"award-number":["R01NS082285"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS086905"],"award-info":[{"award-number":["R01NS086905"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>White matter hyperintensity of presumed vascular origin is a risk factor for poor stroke outcomes. In patients with acute ischemic stroke, however, the in\u00a0vivo mechanisms of white matter microstructural injury are less clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the directional diffusivity components in normal-appearing white matter and white matter hyperintensity in acute ischemic stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on a cohort of patients with acute ischemic stroke and brain magnetic resonance imaging with diffusion tensor imaging sequences acquired within 48\u2009h of admission. White matter hyperintensity volume was measured in a semi-automated manner. Median fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity values were calculated within normal-appearing white matter and white matter hyperintensity in the hemisphere contralateral to the acute infarct. Linear regression analysis was performed to evaluate predictors of white matter hyperintensity volume and normal-appearing white matter diffusivity metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 319 patients, mean age was 64.9\u2009\u00b1\u200915.9 years. White matter hyperintensity volume was 6.33\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      (interquartile range 3.0\u201312.6\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      ). Axial and radial diffusivity were significantly increased in white matter hyperintensity compared to normal-appearing white matter. In multivariable linear regression, age (\u03b2\u2009=\u20090.20, P\u2009=\u20090.003) and normal-appearing white matter axial diffusivity (\u03b2\u2009=\u200937.9, P\u2009&lt;\u20090.001) were independently associated with white matter hyperintensity volume. Subsequent analysis demonstrated that increasing age (\u03b2\u2009=\u20090.004, P\u2009&lt;\u20090.001) and admission diastolic blood pressure (\u03b2\u2009=\u20090.001, P\u2009=\u20090.02) were independent predictors of normal-appearing white matter axial diffusivity in multivariable linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Normal-appearing white matter axial diffusivity increases with age and is an independent predictor of white matter hyperintensity volume in acute ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493019895707","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T02:18:47Z","timestamp":1576635527000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Normal-appearing white matter microstructural injury is associated with white matter hyperintensity burden in acute ischemic stroke"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4739-2449","authenticated-orcid":false,"given":"Mark R","family":"Etherton","sequence":"first","affiliation":[{"name":"Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ona","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA"},{"name":"Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Katrin","family":"Giese","sequence":"additional","affiliation":[{"name":"Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia S","family":"Rost","sequence":"additional","affiliation":[{"name":"Department of Neurology, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"bibr1-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70060-7"},{"key":"bibr2-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"bibr3-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1159\/000337335"},{"key":"bibr4-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a18823"},{"key":"bibr5-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.521906"},{"key":"bibr6-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1996.0086"},{"key":"bibr7-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.07.048"},{"key":"bibr8-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.12.2307"},{"key":"bibr9-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21580"},{"key":"bibr10-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.576629"},{"key":"bibr11-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1267"},{"key":"bibr12-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0071"},{"key":"bibr13-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20774"},{"key":"bibr14-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003890"},{"key":"bibr15-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.3.r99se24785"},{"key":"bibr16-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2005.tb00289.x"},{"key":"bibr17-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2001.0915"},{"key":"bibr18-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.05.013"},{"key":"bibr19-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22236"},{"key":"bibr20-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.07.052"},{"key":"bibr21-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.783"},{"key":"bibr22-1747493019895707","doi-asserted-by":"publisher","DOI":"10.2217\/iim.13.49"},{"key":"bibr23-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4605-08.2009"},{"key":"bibr24-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm294"},{"key":"bibr25-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20872"},{"key":"bibr26-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20102"},{"key":"bibr27-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.068"},{"key":"bibr28-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.10.009"},{"key":"bibr29-1747493019895707","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00208"},{"key":"bibr30-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.01.048"},{"key":"bibr31-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.08.003"},{"key":"bibr32-1747493019895707","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.09.041"},{"key":"bibr33-1747493019895707","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00092"},{"key":"bibr34-1747493019895707","first-page":"1776","volume":"27","author":"Ni H","year":"2006","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493019895707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1747493019895707","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1747493019895707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:18:26Z","timestamp":1777706306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1747493019895707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1177\/1747493019895707"],"URL":"https:\/\/doi.org\/10.1177\/1747493019895707","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,17]]}}}