{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:33:18Z","timestamp":1790389998093,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Factors associated with long-term mortality after spontaneous intracerebral hemorrhage (ICH) have been poorly investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Our objective was to identify variables associated with long-term mortality in a prospective cohort of 30-day ICH survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively included consecutive 30-day spontaneous ICH survivors. We evaluated baseline and follow-up clinical characteristics and magnetic resonance imaging (MRI) markers of chronic brain injury as variables associated with long-term mortality using univariate and multivariable Cox proportional hazard regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 560 patients with spontaneous ICH, 304 (54.2%) survived more than 30 days and consented for follow-up. During a median follow-up of 10 years (interquartile range: 8.0\u201310.5), 176 patients died. The cumulative survival rate at 10 years was 38%. In multivariable analysis, variables independently associated with long-term mortality were age (hazard ratio (HR) per 10-year increase: 1.68, 95% confidence interval (CI): 1.45\u20131.95), male gender (HR: 1.41, CI: 1.02\u20131.95), prestroke dependency (HR: 1.66, CI: 1.15\u20132.39), National Institutes of Health Stroke Scale score (HR per 1-point increase: 1.03, CI: 1.01\u20131.04), occurrence of any stroke (HR: 2.24, CI: 1.39\u20133.60), and dementia (HR: 1.51, CI: 1.06\u20132.16) during follow-up. Among MRI markers, only cerebral atrophy (HR per 1-point increase: 1.50, CI: 1.13\u20132.00) was independently associated with long-term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preexisting comorbidities, clinical severity at presentation, and significant clinical event during follow-up are associated with long-term mortality. Among MRI markers of chronic brain injury, only cerebral atrophy is associated with long-term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493020954946","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T01:16:23Z","timestamp":1599182183000},"page":"448-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Long-term mortality in survivors of spontaneous intracerebral hemorrhage"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-2459","authenticated-orcid":false,"given":"Marco","family":"Pasi","sequence":"first","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-995X","authenticated-orcid":false,"given":"Barbara","family":"Casolla","sequence":"additional","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00e9va","family":"Kyheng","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Public Health, University of Lille, EA 2694, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Lille, Inserm U1171, CHU Lille, Lille, France"},{"name":"Department of Neuroradiology, Paris-Descartes University, Inserm U894, Saint-Anne Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Lille, Inserm U1171, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Moulin","sequence":"additional","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatics and Public Health, University of Lille, EA 2694, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"H\u00e9non","sequence":"additional","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cordonnier","sequence":"additional","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-4392","authenticated-orcid":false,"given":"Didier","family":"Leys","sequence":"additional","affiliation":[{"name":"U1172\u2009-\u2009LilNCog\u2009-\u2009Lille Neuroscience & Cognition, University of Lille, Inserm, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"bibr1-1747493020954946","doi-asserted-by":"crossref","unstructured":"Cordonnier C, Demchuk A, Ziai W and Anderson CS. Intracerebral haemorrhage: current approaches to acute management.\n                      Lancet\n                      2018; 392: 1257\u20131268.","DOI":"10.1016\/S0140-6736(18)31878-6"},{"key":"bibr2-1747493020954946","doi-asserted-by":"crossref","unstructured":"van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A and Klijn CJ. Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis.\n                      Lancet Neurol\n                      2010; 9: 167\u2013176.","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"bibr3-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306476"},{"key":"bibr4-1747493020954946","doi-asserted-by":"crossref","unstructured":"Hemphill JC, Bonovich DC, Besmertis L, Manley GT and Johnston SC. The ICH score.\n                      Stroke\n                      2001; 32: 891\u2013897.","DOI":"10.1161\/01.STR.32.4.891"},{"key":"bibr5-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250340.05202.8b"},{"key":"bibr6-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.512202"},{"key":"bibr7-1747493020954946","doi-asserted-by":"crossref","unstructured":"Vermeer SE, Algra A, Franke CL, Koudstaal PJ and Rinkel GJ. Long-term prognosis after recovery from primary intracerebral haemorrhage.\n                      Neurology\n                      2002; 59: 205\u2013209.","DOI":"10.1212\/WNL.59.2.205"},{"key":"bibr8-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.055145"},{"key":"bibr9-1747493020954946","doi-asserted-by":"crossref","unstructured":"Hansen BM, Nilsson OG, Anderson H, Norrving B, S\u00e4veland H and Lindgren A. Long-term (13 years) prognosis after primary intracerebral haemorrhage: a prospective population based study of long-term mortality, prognostic factors and causes of death.\n                      J Neurol Neurosurg Psychiatry\n                      2013; 84: 1150\u20131155.","DOI":"10.1136\/jnnp-2013-305200"},{"key":"bibr10-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"bibr11-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0030-3"},{"key":"bibr12-1747493020954946","doi-asserted-by":"crossref","unstructured":"Moulin S, Labreuche J, Bombois S, et\u00a0al. Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study.\n                      Lancet Neurol\n                      2016; 15: 820\u2013829. 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Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts.\n                      Eur Neurol\n                      1996; 36: 268\u2013278.","DOI":"10.1159\/000117270"},{"key":"bibr20-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.024449"},{"key":"bibr21-1747493020954946","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8573-1"},{"key":"bibr22-1747493020954946","doi-asserted-by":"crossref","unstructured":"Sacco S, Marini C, Toni D, Olivieri L and Carolei A. 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