{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:32:22Z","timestamp":1793093542738,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Effectiveness of early intensive aphasia rehabilitation after stroke is unknown. The Very Early Rehabilitation for SpEech trial (VERSE) aimed to determine whether intensive aphasia therapy, beginning within 14 days after stroke, improved communication recovery compared to usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, randomized, single-blinded trial conducted at 17 acute-care hospitals across Australia\/New Zealand from 2014 to 2018. Participants with aphasia following acute stroke were randomized to receive usual care (direct usual care aphasia therapy), or one of two higher intensity regimens (20 sessions of either non-prescribed (usual care-plus or prescribed (VERSE) direct aphasia therapy). The primary outcome was improvement of communication on the Western Aphasia Battery-Revised Aphasia Quotient (AQ) at 12 weeks after stroke. Our pre-planned intention to treat analysis combined high intensity groups for the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Among 13,654 acute stroke patients screened, 25% (3477) had aphasia, of whom 25% (866) were eligible and 246 randomized to usual care (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200981; 33%), usual care-plus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200982; 33%) or VERSE (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200983; 34%). At 12 weeks after stroke, the primary outcome was assessed in 217 participants (88%); 14 had died, 9 had withdrawn, and 6 were too unwell for assessment. Communication recovery was 50.3% (95% CI 45.7\u201354.8) in the high intensity group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009147) and 52.1% (95% CI 46.1\u201358.1) in the usual care group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200970; difference \u22121.8, 95% CI \u22128.7\u20135.0). There was no difference between groups in non-fatal or fatal adverse events (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.72).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Early, intensive aphasia therapy did not improve communication recovery within 12 weeks post stroke compared to usual care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1747493020961926","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T04:16:34Z","timestamp":1601957794000},"page":"556-572","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":93,"title":["A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-1295","authenticated-orcid":false,"given":"Erin","family":"Godecke","sequence":"first","affiliation":[{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia"},{"name":"Speech Pathology Department, Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4469-1117","authenticated-orcid":false,"given":"Elizabeth","family":"Armstrong","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan","family":"Rai","sequence":"additional","affiliation":[{"name":"School of Mathematical and Physical Sciences, University of Technology NSW, Broadway, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-7217","authenticated-orcid":false,"given":"Natalie","family":"Ciccone","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-0965","authenticated-orcid":false,"given":"Miranda L","family":"Rose","sequence":"additional","affiliation":[{"name":"School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7201-4394","authenticated-orcid":false,"given":"Sandy","family":"Middleton","sequence":"additional","affiliation":[{"name":"St Vincent\u2019s Health Australia, Sydney and Australian Catholic University, Darlinghurst, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Whitworth","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Curtin University, Bentley, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Holland","sequence":"additional","affiliation":[{"name":"Speech Language Pathology, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Ellery","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J","family":"Hankey","sequence":"additional","affiliation":[{"name":"Medical School, The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-682X","authenticated-orcid":false,"given":"Dominique A","family":"Cadilhac","sequence":"additional","affiliation":[{"name":"Stroke and Ageing Research, School of Clinical Science at Monash Health, Monash University, Clayton, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-8484","authenticated-orcid":false,"given":"Julie","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the VERSE Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"crossref","unstructured":"Brady MC Kelly H Godwin J Enderby P and Campbell P. 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