{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:00:17Z","timestamp":1792476017064,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Advancing age is a major risk factor for ischemic stroke in atrial fibrillation. We aimed to evaluate the predictors of all-cause death\/any thromboembolism and the impact of oral anticoagulant on clinical outcomes in very elderly (\u226585 years) Chinese atrial fibrillation patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ChiOTEAF is a prospective registry proceeded in 44 sites from 20 provinces in China between October 2014 and December 2018. Outcomes of interest were all-cause mortality, any thromboembolism, major bleeding, and new onset\/worsening heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The eligible cohort for this analysis included 6416 patients and 1215 (18.9%) patients were aged \u226585 years. Only 320 (26.4%) very elderly patients were treated with oral anticoagulant, of whom 205 (64.1%) received non-vitamin K antagonist oral anticoagulants, while antiplatelet therapy was used among 642 (53.1%) very elderly patients. On multivariate analysis, the use of oral anticoagulant was an independent predictor of a lower risk of the composite outcome (OR: 0.46; 95% CI: 0.32\u20130.66) and all-cause death (OR: 0.47; 95% CI: 0.32\u20130.69) among these very elderly atrial fibrillation patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Advanced age should not be a reason to withhold oral anticoagulant, since the use of oral anticoagulants is safe and improves survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930211046743","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T01:21:04Z","timestamp":1632360064000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral anticoagulation improves survival in very elderly Chinese patients with atrial fibrillation: A report from the Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) registry"],"prefix":"10.1177","volume":"17","author":[{"given":"Yutao","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Centre, Chinese PLA General Hospital, Beijing, China"},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-3187","authenticated-orcid":false,"given":"Agnieszka","family":"Kotalczyk","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"},{"name":"Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Medical University of Silesia, Silesian Centre for Heart Diseases, Zabrze, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo F","family":"Imberti","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"},{"name":"Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Second Medical Centre, Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory YH","family":"Lip","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Vessel and Thrombotic Disease, Sixth Medical Centre, Chinese PLA General Hospital, Beijing, China"},{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the ChiOTEAF Registry Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"bibr1-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"bibr2-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2017.05.004"},{"key":"bibr3-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"bibr4-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"bibr5-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"bibr6-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"bibr7-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2021.1921738"},{"key":"bibr8-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00459-3"},{"key":"bibr9-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"bibr10-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007199"},{"key":"bibr11-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020191"},{"key":"bibr12-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut373"},{"key":"bibr13-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afv071"},{"key":"bibr14-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"bibr15-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"bibr16-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht280"},{"key":"bibr17-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcaa093"},{"key":"bibr18-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16178"},{"key":"bibr19-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017024"},{"key":"bibr20-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688482"},{"key":"bibr21-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13200"},{"key":"bibr22-17474930211046743","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1095"},{"key":"bibr23-17474930211046743","first-page":"47","volume":"22","author":"Mazurek 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