{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:07:50Z","timestamp":1777943270064,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Effects of early blood pressure (BP) lowering on cerebral perfusion in patients with moderate\/severe occlusive carotid disease after transient ischemic attack (TIA) and non-disabling stroke are uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to evaluate the changes in transcranial Doppler (TCD) indices in patients undergoing blood pressure lowering soon after TIA\/non-disabling stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive eligible patients (1 November 2011 to 30 October 2018) attending a rapid-access clinic with TIA\/non-disabling stroke underwent telemetric home blood pressure monitoring (HBPM) for 1 month and middle cerebral artery velocities measurements ipsilateral to carotid stenosis on TCD ultrasound in the acute setting and at 1 month. Hypertensive patients (HBPM\u2009\u2a7e\u2009135\/85) underwent intensive BP-lowering guided by HBPM unless they had bilateral severe occlusive disease (\u2a7e\u200970%). Changes in BP and TCD parameters were compared in patients with extracranial moderate\/severe carotid stenosis (between 50% and occlusion) versus those with no or mild (&lt;\u200950%) stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 764 patients with repeated TCD measures, 42 had moderate\/severe extracranial carotid stenosis without bilateral severe occlusive disease. HBPM was reduced from baseline to 1 month in hypertensive patients both with versus without moderate\/severe carotid stenosis (\u221212.44\/15.99 vs \u221213.2\/12.2\u2009mmHg, respectively, p-difference\u2009=\u20090.82), and changes in TCD velocities (4.69\/14.94 vs 2.69\/13.86\u2009cm\/s, respectively, p-difference\u2009=\u20090.52 for peak systolic velocity and 0.33\/7.06 vs 1.75\/6.84\u2009cm\/s, p-difference\u2009=\u20090.34 for end-diastolic velocity) were also similar, with no evidence of greater hemodynamic compromise in patients with stenosis\/occlusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There was no evidence of worsening of TCD hemodynamic indices in patients with moderate\/severe occlusive carotid disease treated with BP-lowering soon after TIA\/non-disabling stroke, suggesting that antihypertensive treatment in this group of patients is safe in the acute setting of TIA clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930211068655","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T07:25:52Z","timestamp":1641540352000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebral hemodynamic effects of early blood pressure lowering after TIA and stroke in patients with carotid stenosis"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1582-6724","authenticated-orcid":false,"given":"Sara","family":"Mazzucco","sequence":"first","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-8355","authenticated-orcid":false,"given":"Linxin","family":"Li","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iain J","family":"McGurgan","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Assuncao","family":"Tuna","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Campus Bio-Medico University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy E","family":"Binney","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"bibr1-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06178-5"},{"key":"bibr2-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08485"},{"key":"bibr3-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.2.473"},{"key":"bibr4-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097917"},{"key":"bibr5-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12418"},{"key":"bibr6-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000106480.76217.6F"},{"key":"bibr7-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026823"},{"key":"bibr8-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003368"},{"key":"bibr9-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2499"},{"key":"bibr10-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000094424.38761.56"},{"key":"bibr11-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16405-2"},{"key":"bibr12-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016661565"},{"key":"bibr13-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.1"},{"key":"bibr14-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.8.1148"},{"key":"bibr15-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328335c34f"},{"key":"bibr16-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.200972"},{"key":"bibr17-17474930211068655","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"bibr18-17474930211068655","first-page":"57","volume-title":"Transcranial 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