{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:42:20Z","timestamp":1784169740631,"version":"3.55.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Tirofiban, a glycoprotein IIb\/IIIa receptor inhibitor, has been shown to reduce the risk of thrombotic complications during percutaneous coronary intervention. However, it remains unknown whether tirofiban improves outcomes in large vessel occlusion stroke patients undergoing endovascular treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This trial aims to assess whether additional intravenous tirofiban therapy can improve the clinical outcomes in large vessel occlusion stroke patients who undergo endovascular treatment within 24 h of symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and design:<\/jats:title>\n                    <jats:p>The Endovascular Treatment With versus Without Tirofiban for Stroke Patients With Large Vessel Occlusion (RESCUE BT) Trial is an investigator-initiated, randomized, placebo-controlled, double-blind, multicenter trial. Up to 930 eligible patients will be consecutively randomized to intravenous tirofiban or placebo in 1:1 ratio over 3 years across 50 endovascular-capable stroke centers in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>The primary end point is the disability level as measured by overall distribution of the 90-day modified Rankin Scale scores. Primary safety end points include symptomatic intracerebral hemorrhage at 48 h and mortality at 90\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registry number:<\/jats:title>\n                    <jats:p>ChiCTR-INR-17014167 ( www.chictr.org.cn ).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930211069510","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T06:22:31Z","timestamp":1643264551000},"page":"1151-1155","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Endovascular treatment with versus without tirofiban for stroke patients with large vessel occlusion: The multicenter, randomized, placebo-controlled, double-blind RESCUE BT study protocol"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-9526","authenticated-orcid":false,"given":"Zhongming","family":"Qiu","sequence":"first","affiliation":[{"name":"Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-1499","authenticated-orcid":false,"given":"Fengli","family":"Li","sequence":"additional","affiliation":[{"name":"Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Sang","sequence":"additional","affiliation":[{"name":"Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurology, Wuhan No. 1 Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguo","family":"Huang","sequence":"additional","affiliation":[{"name":"Neurology, Chinese Medical Hospital of Maoming, Maoming, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagang","family":"Li","sequence":"additional","affiliation":[{"name":"Neurology, Zhongnan Hospital, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neurology, Jiangmen Central Hospital, Jiangmen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Neurology, Xiangyang No.1 People\u2019s Hospital, Hubei University of Medicine, Xiangyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lei","sequence":"additional","affiliation":[{"name":"Cerebrovascular Diseases, Leshan People\u2019s Hospital, Leshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Neurology, Yijishan Hospital of Wannan Medical College, Wuhu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Saver","sequence":"additional","affiliation":[{"name":"Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Marcus Stroke & Neuroscience Center, Grady Memorial Hospital, School of Medicine, Emory University, Atlanta, GA, 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