{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:32:55Z","timestamp":1785792775168,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose:<\/jats:title>\n                    <jats:p>In the era of easily available antibiotic use, this study provides epidemiological evidence for a re-examination of the relationship between syphilis and ischemic stroke (IS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Patients aged 18\u2009years and older with newly diagnosed syphilis were included (n\u2009=\u20091585) from 2000 to 2012, and participants without syphilis in the control group (n\u2009=\u20096340) were matched by propensity score (age, sex, index year, insured amount, urbanization, seasons, and comorbidities). The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) of IS. Five different Cox regression models, sensitivity analyses, and negative control were conducted to test our findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 1585 patients (1055 (66.56%) men; mean (SD) age, 49.59 (20.32) years) had syphilis, and 3.8% had new-onset IS. The syphilis group had a higher risk of IS than the controls (adjusted HR, 1.35; 95% CI, 1.01\u20131.80; p value\u2009&lt;\u20090.05) after full adjustment. Serial sensitivity analyses yielded consistent results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Syphilis patients have higher risk of IS, and our data raise the question of implementation of prophylactic treatment for IS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930221079163","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T05:27:46Z","timestamp":1643693266000},"page":"997-1005","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Syphilis and ischemic stroke: Old question revisited by a nationwide cohort study"],"prefix":"10.1177","volume":"17","author":[{"given":"Shu-Han","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsiang","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Hung","sequence":"additional","affiliation":[{"name":"Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Pingtung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Chia","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Pingtung Branch, Pingtung County"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei-Tung","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Management office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-8799","authenticated-orcid":false,"given":"Yao-Min","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-2233","authenticated-orcid":false,"given":"Renin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cheng-Chung Wei","sequence":"additional","affiliation":[{"name":"Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, 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