{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:29:09Z","timestamp":1789241349702,"version":"build-2803163510"},"reference-count":17,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Inserm U1172"},{"name":"Adrinord"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although anxiety is common in several neurological conditions, it has been poorly investigated after spontaneous intracerebral hemorrhage (ICH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>In consecutive ICH survivors, we assessed the long-term prevalence of anxiety and its clinical and radiological determinants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using the Hospital Anxiety and Depression Scale (HADS), we evaluated ICH survivors enrolled in the prospective, single-center Prognosis of Intracerebral Hemorrhage (PITCH) study. The prevalence of anxiety (defined as a HADS-anxiety subscale score &gt;7) was evaluated at three time points (1\u20132, 3\u20135, and 6\u20138\u2009years after ICH), along with neurological symptoms severity, functional disability, and cognitive impairment scores. Clinical and radiological characteristics associated with anxiety were evaluated in univariate and multivariable models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 560 patients with spontaneous ICH, 255 were alive 1\u2009year later, 179 of whom completed the HADS questionnaire and were included in the study. Thirty-one patients (17%; 95% confidence interval (CI)\u2009=\u200912\u201323) had anxiety 1\u20132\u2009years, 38 (27%; 95% CI\u2009=\u200919\u201334) 3\u20135\u2009years, and 18 (21%; 95% CI\u2009=\u200912\u201330) 6\u20138\u2009years after ICH. In patients with anxiety, the prevalence of associated depressive symptoms was 48% 1\u20132\u2009years, 61% 3\u20135\u2009years, and 56% 6\u20138\u2009years after ICH. Among clinical and radiological baseline characteristics, only lobar ICH location was significantly associated with anxiety 1\u20132\u2009years after ICH (odds ratio\u2009=\u20092.8; 95% CI\u2009=\u20091.2\u20136.5). Anxiety was not associated with concomitant neurological symptoms severity, functional disability, or cognitive impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Anxiety is frequent in ICH survivors, often in association with depressive symptoms, even many years after the index event.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930221085443","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T06:57:55Z","timestamp":1645426675000},"page":"1093-1099","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Long-term anxiety in spontaneous intracerebral hemorrhage survivors"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-2124","authenticated-orcid":false,"given":"Giuseppe","family":"Scopelliti","sequence":"first","affiliation":[{"name":"CHU Lille (Department of Neurology), Inserm U1172\u2014LilNCog\u2014Lille Neuroscience & Cognition, Univ. Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-995X","authenticated-orcid":false,"given":"Barbara","family":"Casolla","sequence":"additional","affiliation":[{"name":"CHU Lille (Department of Neurology), Inserm U1172\u2014LilNCog\u2014Lille Neuroscience & Cognition, Univ. Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Inserm UMR 1266, GHU Paris Psychiatrie et Neurosciences, Department of Neuroradiology, Centre Hospitalier Sainte-Anne, Paris University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Kuchcinski","sequence":"additional","affiliation":[{"name":"CHU Lille (Department of Neuroradiology), Inserm U1172\u2014LilNCog\u2014Lille Neuroscience & Cognition, Univ. Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Moulin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centre Hospitalier Universitaire Reims, H\u00f4pital Maison Blanche, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Leys","sequence":"additional","affiliation":[{"name":"CHU Lille (Department of Neurology), Inserm U1172\u2014LilNCog\u2014Lille Neuroscience & Cognition, Univ. Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"H\u00e9non","sequence":"additional","affiliation":[{"name":"CHU Lille (Department of Neurology), Inserm U1172\u2014LilNCog\u2014Lille Neuroscience & Cognition, Univ. 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