{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:07:47Z","timestamp":1777943267882,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from the initial bleeding cannot currently be influenced, secondary injury through vasospasm and delayed cerebral ischemia worsens outcome and might be a target for interventions to improve outcome. To date, beside the aneurysm treatment to prevent re-bleeding and the administration of oral nimodipine, there is no therapy available, so novel treatment concepts are needed. Evidence suggests that inflammation contributes to delayed cerebral ischemia and poor outcome in SAH. Some studies suggest a beneficial effect of anti-inflammatory glucocorticoids, but there are no data from randomized controlled trials examining the efficacy of glucocorticoids. Therefore, current guidelines do not recommend the use of glucocorticoids in SAH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial aims to determine whether dexamethasone improves outcome in a clinically relevant endpoint in SAH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and design:<\/jats:title>\n                    <jats:p>FINISHER is a multicenter, prospective, randomized, double-blinded, placebo-controlled clinical phase III trial which is testing the outcome and safety of anti-inflammatory treatment with dexamethasone in SAH patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample size estimates:<\/jats:title>\n                    <jats:p>In all, 334 patients will be randomized to either dexamethasone or placebo within 48\u2009h after SAH. The dexamethasone dose is 8\u2009mg tds for days 1\u20137 and then 8\u2009mg od for days 8\u201321.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study outcome:<\/jats:title>\n                    <jats:p>The primary outcome is the modified Rankin Scale (mRS) at 6\u2009months, which is dichotomized to favorable (mRS 0\u20133) versus unfavorable (mRS 4\u20136).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The results of this study will provide the first phase III evidence as to whether dexamethasone improves outcome in SAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930221093501","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T04:52:23Z","timestamp":1648788743000},"page":"242-247","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial: Study protocol for a randomized controlled trial"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-0847","authenticated-orcid":false,"given":"Erdem","family":"G\u00fcresir","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2607-2024","authenticated-orcid":false,"given":"Tim","family":"Lampmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Bele","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Czabanka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johann Wolfgang Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Czorlich","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Gempt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Goldbrunner","sequence":"additional","affiliation":[{"name":"Department of General Neurosurgery, Center for Neurosurgery, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Hurth","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvis","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Jabbarli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Krauthausen","sequence":"additional","affiliation":[{"name":"Clinical Study Core Unit, Study Center Bonn (SZB), University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Ulm\/BKH G\u00fcnzburg, G\u00fcnzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Malinova","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Georg-August-Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Meixensberger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothee","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Georg-August-Universit\u00e4t G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1021-5024","authenticated-orcid":false,"given":"Marvin","family":"Darkwah Oppong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Spine Surgery, University Hospital of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6653-701X","authenticated-orcid":false,"given":"Andrej","family":"Pala","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Ulm\/BKH G\u00fcnzburg, G\u00fcnzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Prinz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johann Wolfgang Goethe-Universit\u00e4t Frankfurt am Main, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"Roder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eberhard Karls University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Erol","family":"Sandalcioglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otto von Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sauvigny","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Michael","family":"Schebesch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Timmer","sequence":"additional","affiliation":[{"name":"Department of General Neurosurgery, Center for Neurosurgery, University of Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Wessels","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wostrack","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut","family":"Vatter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Coch","sequence":"additional","affiliation":[{"name":"Clinical Study Core Unit, Study Center Bonn (SZB), University Hospital Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"bibr1-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70017-5"},{"key":"bibr2-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60153-6"},{"key":"bibr3-17474930221093501","volume":"3","author":"Feigin VL","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr4-17474930221093501","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00292"},{"key":"bibr5-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19841443"},{"key":"bibr6-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003319"},{"key":"bibr7-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.05.025"},{"key":"bibr8-17474930221093501","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122580"},{"key":"bibr9-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9091-5"},{"key":"bibr10-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2017.10.051"},{"key":"bibr11-17474930221093501","doi-asserted-by":"publisher","DOI":"10.3171\/2009.4.JNS081377"},{"key":"bibr12-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13265"},{"key":"bibr13-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.12.1044"},{"key":"bibr14-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02184-x"},{"key":"bibr15-17474930221093501","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7547-8-6"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930221093501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930221093501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930221093501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:20:48Z","timestamp":1777706448000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930221093501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1177\/17474930221093501"],"URL":"https:\/\/doi.org\/10.1177\/17474930221093501","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,3]]}}}