{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:38:43Z","timestamp":1793529523223,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Research investigating differences in the overall stroke risk between individuals with and without immune thrombocytopenia (ITP) is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This real-world study used the National Health Insurance Research Database (NHIRD). Risk of stroke was compared between 13,085 individuals with ITP enrolled between 1 January 2000 and 31 December 2015 and a control cohort of 52,340 individuals without ITP (1:4 ratio propensity score\u2013matched by age, sex, index year, relevant comorbidities, and medications). Sub-distribution hazards models were used to estimate adjusted sub-distribution hazard ratio (SHR) and 95% confidence intervals (CIs), with the non-ITP group as the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 65,425 participants, 13,085 had ITP, 63.3% were women, and the mean age was 52.59\u2009years. The risk of both ischemic and hemorrhagic stroke was 1.14 times (adjusted SHR 1.14, 95% CI, 1.07\u20131.22) and 1.93 times (adjusted SHR 1.93, 95% CI, 1.70\u20132.20) higher in the ITP group than in controls. Patients with ITP in the 20- to 29-year subgroup had a higher risk of new-onset stroke (adjusted SHR, 4.06 (95% CI, 2.72\u20136.07), p value for interaction &lt;0.01) than those aged 20\u201329\u2009years without ITP. Individuals with severe ITP with splenectomy had a 1.79 times higher overall stroke risk than those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ITP is associated with increased risk of both ischemic and hemorrhagic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930221125556","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T06:30:52Z","timestamp":1662618652000},"page":"408-415","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Immune thrombocytopenia and risk of stroke: Evidence from a nationwide population-based cohort study"],"prefix":"10.1177","volume":"18","author":[{"given":"Hsin-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Kai","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Sinying Hospital, Ministry of Health and Welfare, Tainan"},{"name":"Min-Hwei Junior College of Health Care Management, Tainan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-2233","authenticated-orcid":false,"given":"Renin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-8799","authenticated-orcid":false,"given":"Yao-Min","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung"},{"name":"College of Health and Nursing, Meiho University, Pingtung"},{"name":"Institute of Medicine, Chung Shan Medical University, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Y","family":"Hsu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hsiu","family":"Shih","sequence":"additional","affiliation":[{"name":"Management Office for Health Data (DryLab), Clinical Trial Research Center (CTC), China Medical University Hospital, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Shuen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Administration, Kaohsiung Veterans General Hospital, Kaohsiung"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"bibr1-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"bibr2-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07615.x"},{"key":"bibr3-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.3.909.415k02_909_913"},{"key":"bibr4-17474930221125556","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6020016"},{"key":"bibr5-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-129262"},{"key":"bibr6-17474930221125556","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.046417"},{"key":"bibr7-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281717"},{"key":"bibr8-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14446"},{"key":"bibr9-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175556"},{"key":"bibr10-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13940"},{"key":"bibr11-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0636-3"},{"key":"bibr12-17474930221125556","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13787"},{"key":"bibr13-17474930221125556","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018390"},{"key":"bibr14-17474930221125556","first-page":"334","volume":"119","author":"Jy 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