{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:15Z","timestamp":1787019315540,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-029"],"award-info":[{"award-number":["2019-I2M-5-029"]}]},{"name":"the Capital's Funds for Health Improvement and Research","award":["2020-1-2041"],"award-info":[{"award-number":["2020-1-2041"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870905, U20A20358"],"award-info":[{"award-number":["81870905, U20A20358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC2502400, 2022YFC2502404"],"award-info":[{"award-number":["2022YFC2502400, 2022YFC2502404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anti-inflammatory therapy using colchicine has reduced recurrent vascular events in patients with coronary heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Colchicine in High-risk Patients with Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3) is a randomized, double-blind, placebo-controlled multicenter trial, in which 8,238 patients with acute minor-to-moderate ischemic stroke (NIHSS\u2009\u2a7d\u20095) or high-risk transient ischemic attack (TIA) (ABCD\n                      <jats:sup>2<\/jats:sup>\n                      score \u2a7e4) and a high-sensitivity CRP (hsCRP) level of \u2a7e2\u2009mg\/L will be randomly assigned within 24\u2009h of symptom onset to colchicine (1\u2009mg daily on days 1\u20133, followed by 0.5\u2009mg daily for a total of 90\u2009days) or matching placebo, on a background of optimal medical therapy. The study will have 90% power to detect a 25% reduction in the primary efficacy outcome of any stroke within 3\u2009months of randomization. Adverse events potentially related to the use of colchicine will also be analyzed. The primary analysis will be by intention to treat.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registry name:<\/jats:title>\n                    <jats:p>Colchicine in High-risk Patients with Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3); URL: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05439356?cond=CHANCE-3&amp;draw=2&amp;rank=1 ; Registration number: NCT05439356.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231172312","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T06:11:20Z","timestamp":1681539080000},"page":"873-878","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Colchicine in High-risk Patients with Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3): Rationale and design of a multicenter randomized placebo-controlled trial"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-2341","authenticated-orcid":false,"given":"Yongjun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, and China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Clinical Center for Precision Medicine in Stroke, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-4843","authenticated-orcid":false,"given":"Jiejie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, and China National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S 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