{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:39:10Z","timestamp":1790285950478,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Although men have a higher rate of stroke than women, it is not clear whether women have a worse outcome after adjusting for confounders such as vascular risk factors, age, stroke severity, and reperfusion therapy. We evaluated sex differences on 90-day functional outcomes after stroke in a multicenter study in Vietnam.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We recruited patients presenting with ischemic or hemorrhagic stroke at 10 stroke centers in Vietnam for a period of 1\u2009month from 1 August 2022 to 31 August 2022. We reviewed the patient\u2019s clinical demographics, time from symptom onset to hospital admission, stroke classification, stroke subtype, stroke severity, characteristics of reperfusion therapy, and 90-day clinical outcome. We compared functional outcomes and predisposing factors at day 90 between men and women after an ischemic and hemorrhagic stroke. Poor outcome was defined as modified Rankin Scale 3\u20136.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 2300 stroke patients included. Men accounted for 61.3% (1410) of participants. Compared to men, women were older (67.7\u2009\u00b1\u200913.9 vs 63.7\u2009\u00b1\u200913.3, P\u2009&lt;\u20090.001), had a higher rate of diabetes mellitus (21.1% vs 15.3%, P\u2009&lt;\u20090.001), a lower rate of tobacco use (1.0 % vs 23.6%, P\u2009&lt;\u20090.001), and a lower body mass index (21.4\u2009\u00b1\u20092.70 vs 22.0\u2009\u00b1\u20092.72, P\u2009&lt;\u20090.001). There was a higher rate of intracranial hemorrhage (ICH) in men (21.3% vs 15.6%, P\u2009=\u20090.001), whereas the rate of subarachnoid hemorrhage was higher in women (6.2% vs 3.0%, P\u2009&lt;\u20090.001). For ischemic stroke, door-to-needle time (36.9\u2009\u00b1\u200917.6 vs 47.8\u2009\u00b1\u200935.2\u2009min, P\u2009=\u20090.04) and door-to-recanalization time (113.6\u2009\u00b1\u200951.1 vs 134.2\u2009\u00b1\u200948.2, P\u2009=\u20090.03) were shorter in women. There was no difference in 90-day functional outcomes between sexes. Factors associated with poor outcomes included age \u2a7e50\u2009years (adjusted odds ratio (aOR): 1.75; 95% confidence interval (CI): 1.16\u20132.66), history of stroke (aOR: 1.50; 95% CI: 1.15\u20131.96), large artery atherosclerosis (aOR: 5.19; 95% CI: 3.90\u20136.90), and cardioembolism (aOR: 3.21; 95% CI: 1.68\u20136.16). Factors associated with mortality in patients with acute ischemic stroke included a history of coronary artery disease (aOR: 3.04; 95% CI: 1.03\u20138.92), large artery atherosclerosis (aOR: 3.37; 95% CI: 2.11\u20135.37), and cardioembolism (aOR: 3.15; 95% CI: 1.20\u20138.27).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There were no sex differences in the clinical outcome of stroke and ischemic stroke in this prospective cohort of hospitalized Vietnamese patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231177893","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:33:23Z","timestamp":1684204403000},"page":"1102-1111","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Sex disparity in stroke outcomes in a multicenter prospective stroke registry in Vietnam"],"prefix":"10.1177","volume":"18","author":[{"given":"Mai Duy","family":"Ton","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam"},{"name":"Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3542-2399","authenticated-orcid":false,"given":"Phuong Viet","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam"},{"name":"Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1385-9116","authenticated-orcid":false,"given":"Dung Tien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam"},{"name":"Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thang Huy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Department, People\u2019s Hospital 115, Ho Chi Minh City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuong Chi","family":"Tran","sequence":"additional","affiliation":[{"name":"Stroke International Services (SIS) General Hospital, Can Tho, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Quang","family":"Duong","sequence":"additional","affiliation":[{"name":"Da Nang Hospital, Da Nang, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Nghe An Friendship General Hospital, Vinh, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam Hoanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Thanh Hoa General Hospital, Thanh Hoa, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen Thi","family":"Bui","sequence":"additional","affiliation":[{"name":"Thai Nguyen National Hospital, Thai Nguyen, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc Phuc","family":"Dang","sequence":"additional","affiliation":[{"name":"Military Medical Academy, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nham Thi","family":"Dao","sequence":"additional","affiliation":[{"name":"Ninh Binh General Hospital, Ninh Binh, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thi Thu","family":"Bui","sequence":"additional","affiliation":[{"name":"Phu Tho General Hospital, Phu Tho City, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Bui","family":"Hoang","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Hanoi Medical University Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoi Hong","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Stroke and Cerebrovascular Disease, Faculty of Stroke and Cerebrovascular Disease, University of Medicine & Pharmacy, Vietnam National University, Hanoi, Vietnam"},{"name":"Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam"},{"name":"Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinh Duy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Heart Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tho Quang","family":"Pham","sequence":"additional","affiliation":[{"name":"Stroke Center, Center of Neurology, Bach Mai Hospital, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-1685","authenticated-orcid":false,"given":"Thanh N","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Radiology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 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